Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke

KM Baeten, K Akassoglou - Developmental neurobiology, 2011 - Wiley Online Library
The blood–brain barrier (BBB) is formed primarily to protect the brain microenvironment from
the influx of plasma components, which may disturb neuronal functions. The BBB is a …

The role of astrocytes in the neurorepair process

RA Chiareli, GA Carvalho, BL Marques… - Frontiers in cell and …, 2021 - frontiersin.org
Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of
neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and …

Brain endothelial cells and the glio-vascular complex

H Wolburg, S Noell, A Mack, K Wolburg-Buchholz… - Cell and tissue …, 2009 - Springer
We present and discuss the role of endothelial and astroglial cells in managing the blood-
brain barrier (BBB) and aspects of pathological alterations in the BBB. The impact of …

New insights into the roles of agrin

G Bezakova, MA Ruegg - Nature Reviews Molecular Cell Biology, 2003 - nature.com
The heparan sulphate proteoglycan agrin is expressed as several isoforms in various
tissues. Agrin is best known as a crucial organizer of postsynaptic differentiation at the …

Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae

A Warth, S Kröger, H Wolburg - Acta neuropathologica, 2004 - Springer
Vasogenic edema is one of the most serious clinical problems in brain tumors and tightly
connected to water shifts between the different fluid compartments in the brain. Aquaporin …

Structure and functions of aquaporin-4-based orthogonal arrays of particles

H Wolburg, K Wolburg-Buchholz… - International review of …, 2011 - Elsevier
Orthogonal arrays or assemblies of intramembranous particles (OAPs) are structures in the
membrane of diverse cells which were initially discovered by means of the freeze-fracturing …

Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier

H Wolburg, S Noell, K Wolburg-Buchholz… - The …, 2009 - journals.sagepub.com
The blood-brain barrier (BBB) does not exclusively refer to brain endothelial cells, which are
the site of the barrier proper. In the past few years, it has become increasingly clear that BBB …

Na, K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis

D Zhang, Q Hou, M Wang, A Lin, L Jarzylo… - Journal of …, 2009 - Soc Neuroscience
Neuronal activity largely depends on two key components on the membrane: the Na, K-
ATPase (NKA) that maintains the ion gradients and sets the foundation of excitability, and …

Synaptogenesis in the developing mouse visual cortex

M Li, Z Cui, Y Niu, B Liu, W Fan, D Yu, J Deng - Brain research bulletin, 2010 - Elsevier
We used transmission electron microscopy to study ultrastructural changes accompanying
synaptogenesis in the fetal and postnatal mouse visual cortex (primary visual cortex) …

Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion

S Solé, V Petegnief, R Gorina… - … of Neuropathology & …, 2004 - academic.oup.com
Abstract Matrix metalloproteinase-3 (MMP-3) degrades components of the extracellular
matrix and may participate in the pathogenesis of stroke. Here we examine the expression …