Acute graft-versus-host disease—biologic process, prevention, and therapy

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
When T cells from a bone marrow donor begin to attack the host within 3 months after
hematopoietic-cell transplantation, acute graft-versus-host disease results. The disease …

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

H Döhner, E Estey, D Grimwade… - Blood, The Journal …, 2017 - ashpublications.org
The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and
management of acute myeloid leukemia (AML) in adults, published in 2010, has found …

Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis

J Bolaños-Meade, M Hamadani, J Wu… - … England Journal of …, 2023 - Mass Medical Soc
Background In patients undergoing allogeneic hematopoietic stem-cell transplantation
(HSCT), a calcineurin inhibitor plus methotrexate has been a standard prophylaxis against …

Randomized phase III BMT CTN trial of calcineurin inhibitor–free chronic graft-versus-host disease interventions in myeloablative hematopoietic cell transplantation for …

L Luznik, MC Pasquini, B Logan, RJ Soiffer… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Calcineurin inhibitors (CNI) are standard components of graft-versus-host
disease (GVHD) prophylaxis after hematopoietic cell transplantation (HCT). Prior data …

Mesenchymal stem cells: immune evasive, not immune privileged

JA Ankrum, JF Ong, JM Karp - Nature biotechnology, 2014 - nature.com
The diverse immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) may
be exploited for treatment of a multitude of inflammatory conditions. MSCs have long been …

[HTML][HTML] The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health Consensus Development Project on Criteria for …

KR Cooke, L Luznik, S Sarantopoulos, FT Hakim… - Biology of Blood and …, 2017 - Elsevier
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis

SR Goldsmith, MB Abid, JJ Auletta… - Blood, The Journal …, 2021 - ashpublications.org
Prior studies suggest increased cytomegalovirus (CMV) infection after haploidentical donor
transplantation with posttransplant cyclophosphamide (HaploCy). The role of allograft …

Three prophylaxis regimens (tacrolimus, mycophenolate mofetil, and cyclophosphamide; tacrolimus, methotrexate, and bortezomib; or tacrolimus, methotrexate, and …

J Bolaños-Meade, R Reshef, R Fraser, M Fei… - The Lancet …, 2019 - thelancet.com
Background Prevention of graft-versus-host disease (GvHD) without malignant relapse is the
overall goal of allogeneic haemopoietic cell transplantation (HCT). We aimed to evaluate …

Classification systems for chronic graft-versus-host disease

SJ Lee - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Chronic graft versus host disease (GVHD) is a major cause of morbidity and mortality after
allogeneic hematopoietic cell transplantation. Clinically, chronic GVHD is a pleiotropic …

Modern approaches to HLA-haploidentical blood or marrow transplantation

CG Kanakry, EJ Fuchs, L Luznik - Nature reviews Clinical oncology, 2016 - nature.com
Allogeneic blood or bone-marrow transplantation (alloBMT) is a potentially curative
treatment for a variety of haematological malignancies and nonmalignant diseases …