The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

One year update on the COVID-19 pandemic: Where are we now?

SK Mishra, T Tripathi - Acta tropica, 2021 - Elsevier
We are living through an unprecedented crisis with the rapid spread of the new coronavirus
disease (COVID-19) worldwide within a short time. The timely availability of thousands of …

Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights

S Ali, M Alam, F Khatoon, U Fatima, AM Elasbali… - Biomedicine & …, 2022 - Elsevier
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more
than three hundred million individuals and resulted in more than five million deaths …

Candidate antiviral drugs for COVID-19 and their environmental implications: a comprehensive analysis

P Biswas, MM Hasan, D Dey… - … Science and Pollution …, 2021 - Springer
Abstract Emerging from Wuhan, China, SARS-CoV-2 is the new global threat that killed
millions of people, and many are still suffering. This pandemic has not only affected people …

[HTML][HTML] Therapeutic dilemmas in addressing SARS-CoV-2 infection: Favipiravir versus Remdesivir

PA Negru, AF Radu, CM Vesa, T Behl… - Biomedicine & …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) represents an unmet clinical need, due to a
high mortality rate, rapid mutation rate in the virus, increased chances of reinfection, lack of …

Therapeutic implications and clinical manifestations of thymoquinone

M Alam, GM Hasan, MM Ansari, R Sharma, DK Yadav… - Phytochemistry, 2022 - Elsevier
Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has
been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and …

Inflammatory pathways in COVID‐19: mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …

Interleukin 6, soluble interleukin 2 receptor alpha (CD25), monocyte colony-stimulating factor, and hepatocyte growth factor linked with systemic hyperinflammation …

L Quartuccio, M Fabris, A Sonaglia, M Peghin… - Cytokine, 2021 - Elsevier
Background Patients infected by SARS-CoV-2 can develop interstitial pneumonia, requiring
hospitalisation or mechanical ventilation. Increased levels of inflammatory biomarkers are …

COVID-19 immunobiology: lessons learned, new questions arise

A Kaklamanos, K Belogiannis, P Skendros… - Frontiers in …, 2021 - frontiersin.org
There is strong evidence that COVID-19 pathophysiology is mainly driven by a
spatiotemporal immune deregulation. Both its phenotypic heterogeneity, spanning from …

Structure-based identification of potential SARS-CoV-2 main protease inhibitors

S Khan, Z Fakhar, A Hussain, A Ahmad… - Journal of …, 2022 - Taylor & Francis
To address coronavirus disease (COVID-19), currently, no effective drug or vaccine is
available. In this regard, molecular modeling approaches are highly useful to discover …