In this perspective, we describe how developmental improvements in youth executive
function (EF) are supported by hierarchically organized maturational changes in functional …

Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …

Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be
measured by assessing functional connectivity (FC) at resting-state functional MRI, that may …

Healthy aging has been associated with a decrease in functional network specialization.
Importantly, variability of alterations of functional connectivity is especially high across older …

This review focuses on possible contributions of neural dedifferentiation to age-related
cognitive decline. Neural dedifferentiation is held to reflect a breakdown in the functional …

Decrement in processing speed (PS) is a primary cognitive morbidity in clinical populations
and could significantly influence other cognitive functions, such as attention and memory …

Background Resting motor threshold is an objective measure of cortical excitability.
Numerous studies indicate that the success of motor recovery after stroke is significantly …

Older drivers are at a severely higher risk for motor vehicle crash involvement. Due to the
global aging of the population, this increased crash risk has a significant impact on society …

Physiological aging causes a decline of motor function due to impairment of motor cortex
function, losses of motor neurons and neuromuscular junctions, sarcopenia, and frailty …

Deficits in auditory nerve (AN) function for older adults reduce afferent input to the cortex.
The extent to which the cortex in older adults adapts to this loss of afferent input and the …