Targeting epigenetics: A novel promise for Alzheimer's disease treatment
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
Neuroepigenetics of ageing and neurodegeneration-associated dementia: an updated review
Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …
Transgenerational Epigenetic DNA Methylation Editing and Human Disease
JD Tompkins - Biomolecules, 2023 - mdpi.com
During gestation, maternal (F0), embryonic (F1), and migrating primordial germ cell (F2)
genomes can be simultaneously exposed to environmental influences. Accumulating …
genomes can be simultaneously exposed to environmental influences. Accumulating …
Neuroprotective factors affect the progression of Alzheimer's disease
Y Liu, J Tian - Biochemical and Biophysical Research …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease that occurs mostly in the elderly
and is characterized by chronic progressive cognitive dysfunction, which seriously threatens …
and is characterized by chronic progressive cognitive dysfunction, which seriously threatens …
Gut microbiota defined epigenomes of Alzheimer's and Parkinson's diseases reveal novel targets for therapy
S Nohesara, HM Abdolmaleky, S Thiagalingam… - …, 2024 - Taylor & Francis
The origins of Alzheimer's disease (AD) and Parkinson's disease (PD) involve genetic
mutations, epigenetic changes, neurotoxin exposure and gut microbiota dysregulation. The …
mutations, epigenetic changes, neurotoxin exposure and gut microbiota dysregulation. The …
Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late‐onset dementia due to Alzheimer's disease
INTRODUCTION DNA microarray‐based studies report differentially methylated positions
(DMPs) in blood between late‐onset dementia due to Alzheimer's disease (AD) and …
(DMPs) in blood between late‐onset dementia due to Alzheimer's disease (AD) and …
Stability of genomic imprinting and X-chromosome inactivation in the aging brain
Epigenetic drift is a hallmark of aging that contributes to the irreversible decline in
organismal fitness ultimately leading to aging-related diseases. Epigenetic modifications …
organismal fitness ultimately leading to aging-related diseases. Epigenetic modifications …
Integrated analyses of 5mC, 5hmC methylation and gene expression reveal pathology-associated AKT3 gene and potential biomarkers for Alzheimer's disease
Y Shen, W Zhu, S Li, Z Zhang, J Zhang, M Li… - Journal of Psychiatric …, 2024 - Elsevier
Aims 5mC methylation and hydroxymethylation (5hmC) are associated with Alzheimer's
disease (AD). However, previous studies were limited by the absence of a 5hmC calculation …
disease (AD). However, previous studies were limited by the absence of a 5hmC calculation …
Extended genome‐wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of …
NR Ray, BW Kunkle, K Hamilton‐Nelson… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Despite a two‐fold risk, individuals of African ancestry have been
underrepresented in Alzheimer's disease (AD) genomics efforts. METHODS Genome‐wide …
underrepresented in Alzheimer's disease (AD) genomics efforts. METHODS Genome‐wide …
Tau protein modulates an epigenetic mechanism of cellular senescence in human SH-SY5Y neuroblastoma cells
C Magrin, M Bellafante, M Sola, E Piovesana… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Progressive Tau deposition in neurofibrillary tangles and neuropil threads is
the hallmark of tauopathies, a disorder group that includes Alzheimer's disease. Since Tau is …
the hallmark of tauopathies, a disorder group that includes Alzheimer's disease. Since Tau is …