The neurological injury and repair mechanisms after ischemic stroke are complex. The
inflammatory response is present throughout stroke onset and functional recovery, in which …

Ischemic stroke is one of the most cases worldwide, with high rate of morbidity and mortality.
In the pathological process of ischemic stroke, neuroinflammation is an essential process …

Abstract Background Stroke affects 3–4% of adults and kills numerous people each year.
Recovering blood flow with minimal reperfusion-induced injury is crucial. However, the …

Background Dihydromyricetin (DHM) exerts protective effects in various brain diseases. The
aim of this research was to investigate the biological role of DHM in cerebral ischemia …

Ischemic stroke (IS) is a multifactorial disease caused by the interaction of multiple
environmental and genetic risk factors, and it is the most common cause of disability. The …

Background Toll-like receptor 2 and Toll-like receptor 4 (TLR2/4) on microglia have been
found as important regulators in the inflammatory response during cerebral …

Idiopathic pulmonary fibrosis is an agnogenic chronic disorder with high morbidity and low
survival rate. Quercetin is a flavonoid found in a variety of herbs with anti-fibrosis function. In …

Sphingosine 1-phosphate (S1P) is involved in a variety of cellular responses including
microglial activation and polarization. However, the impacts of S1P on ischemia-induced …

Cerebral ischemic injury exhibits both high morbidity and mortality worldwide. Traditional
research of the pathogenesis of cerebral ischemic injury has focused on separate analyses …

Background: NLRP3 inflammasome plays a prominent role in the pathogenesis and
progression of many diseases, such as type 2 diabetes mellitus, obesity, atherosclerosis …