APOE4 homozygosity is a new genetic form of Alzheimer’s disease | Nature Medicine Skip to
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APOE4 is widely recognized as a genetic risk factor for Alzheimer's disease (AD), implicated
in 60–80% of all AD cases. Recent research suggests that microglia carrying the APOE4 …

The pathophysiology of many neuropsychiatric disorders is still poorly understood.
Identification of biomarkers for these diseases could benefit patients due to better …

The full impact of apolipoprotein E4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on neuronal and network function remains unclear. We found hippocampal …

Abstract Background Apolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for
late‐onset Alzheimer's disease, and it can aggravate depressive symptoms in non‐AD …

Mortality rate increases with age and can accelerate upon extrinsic or intrinsic damage to
individuals. Identifying factors and mechanisms that curb population mortality rate has wide …

The apolipoprotein E4 (APOE4) allele represents the major genetic risk factor for Alzheimers
disease (AD). In contrast, APOE2 is known to lower the AD risk while APOE3 is defined as …

Variants of the Apolipoprotein E (APOE) gene, particularly the E4 allele, are significantly
associated with an increased risk of Alzheimer's Disease and have been implicated in …

While aggregated alpha-Synuclein (αSyn) is commonly associated with Parkinson's
disease, its physiological function as a membrane-binding protein is poorly understood …

Genetic polymorphism of apolipoprotein E (APOE) confers differential susceptibility to
Alzheimer's disease (AD), and APOE ɛ4 variants is the most powerful risk factor for this …