The genetic landscape of substance use disorders
Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …
socioeconomic implications worldwide. Twin and family-based studies have long …
[HTML][HTML] Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence: Gene X Environment Effects and Moderated Mediation
Background Adverse childhood events (ACEs) contribute to the development of mood and
anxiety disorders and substance dependence. However, the extent to which these effects …
anxiety disorders and substance dependence. However, the extent to which these effects …
A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra
There is considerable comorbidity across externalizing and internalizing behavior
dimensions of psychopathology. We applied genomic structural equation modeling (gSEM) …
dimensions of psychopathology. We applied genomic structural equation modeling (gSEM) …
A single-nucleus transcriptomic atlas of medium spiny neurons in the rat nucleus accumbens
Neural processing of rewarding stimuli involves several distinct regions, including the
nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons …
nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons …