Recent Advancements in the Therapeutic Development for Marburg Virus: Updates on Clinical Trials

G Sharma, AR Sharma, JC Kim - Current Infectious Disease Reports, 2024 - Springer
Abstract Purpose of Review We aim to provide valuable insights into the current state of
therapeutic development for the deadly Marburg virus and guide researchers and clinicians …

Molecular insights into the Ebola virus life cycle

BS Bodmer, T Hoenen, L Wendt - Nature Microbiology, 2024 - nature.com
Ebola virus and other orthoebolaviruses cause severe haemorrhagic fevers in humans, with
very high case fatality rates. Their non-segmented single-stranded RNA genome encodes …

CryoEM of viral ribonucleoproteins and nucleocapsids of single-stranded RNA viruses

A Modrego, D Carlero, R Arranz, J Martín-Benito - Viruses, 2023 - mdpi.com
Single-stranded RNA viruses (ssRNAv) are characterized by their biological diversity and
great adaptability to different hosts; traits which make them a major threat to human health …

Navigating the complex landscape of ebola infection treatment: A review of emerging pharmacological approaches

F Almeida-Pinto, R Pinto, J Rocha - Infectious Diseases and Therapy, 2024 - Springer
In 1976 Ebola revealed itself to the world, marking the beginning of a series of localized
outbreaks. However, it was the Ebola outbreak that began in 2013 that incited fear and …

The 3′ Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay

EV Nelson, SJ Ross, J Olejnik, AJ Hume… - The Journal of …, 2023 - academic.oup.com
Abstract The 3′ untranslated regions (UTRs) of Ebola virus (EBOV) mRNAs are enriched in
their AU content and therefore represent potential targets for RNA binding proteins targeting …

[HTML][HTML] Biomolecular phase separation in stress granule assembly and virus infection: Stress granule and virus infection

Y Liu, Z Yao, G Lian, P Yang - Acta Biochimica et Biophysica Sinica, 2023 - ncbi.nlm.nih.gov
Liquid-liquid phase separation (LLPS) has emerged as a crucial mechanism for cellular
compartmentalization. One prominent example of this is the stress granule. Found in various …

An antiviral role for TRIM14 in Ebola virus infection

M Kuroda, PJ Halfmann, LB Thackray… - The Journal of …, 2023 - academic.oup.com
Ebola virus (EBOV) is a highly pathogenic virus that encodes 7 multifunctional structural
proteins. Multiple host factors have been reported to interact with the EBOV proteins. Here …

Structural insights on the nucleoprotein C-terminal domain of Měnglà virus

DS Ferrero, O Tomás Gilabert… - Microbiology …, 2023 - Am Soc Microbiol
Filoviruses depend on the nucleoprotein (NP) to accomplish multiple functions during the
viral life cycle. NP is the most abundantly expressed viral protein in infected cells and the …

Current Advances in Marburg Virus Disease

EK Ofori, ENY Nyarko - Rising Contagious Diseases: Basics …, 2024 - Wiley Online Library
The Marburg virus (MARV), which causes hemorrhagic fever, is a member of the filovirus
family. After the first documented case in 1967, which occurred at the same time in Germany …

O‐glycosylation in viruses: A sweet tango

A Ming, J Zhao, Y Liu, Y Wang, X Wang, J Li, L Zhang - Mlife, 2024 - Wiley Online Library
O‐glycosylation is an ancient yet underappreciated protein posttranslational modification, on
which many bacteria and viruses heavily rely to perform critical biological functions involved …