[HTML][HTML] Recent advances in SARS-CoV-2 main protease inhibitors: from nirmatrelvir to future perspectives
A Citarella, A Dimasi, D Moi, D Passarella, A Scala… - Biomolecules, 2023 - mdpi.com
The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …
syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target …
The expanding repertoire of covalent warheads for drug discovery
The reactive functionalities of drugs that engage in covalent interactions with the
enzyme/receptor residue in either a reversible or an irreversible manner are …
enzyme/receptor residue in either a reversible or an irreversible manner are …
Targeted degrader technologies as prospective SARS-CoV-2 therapies
R Khurshid, JM Schulz, J Hu, TS Snowden… - Drug discovery today, 2023 - Elsevier
COVID-19 remains a severe public health threat despite the WHO declaring an end to the
public health emergency in May 2023. Continual development of SARS-CoV-2 variants with …
public health emergency in May 2023. Continual development of SARS-CoV-2 variants with …
Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review
YQ Xiao, J Long, SS Zhang, YY Zhu, SX Gu - Bioorganic Chemistry, 2024 - Elsevier
The COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm
for research & development of effective anti-coronavirus drugs, which are crucial for the …
for research & development of effective anti-coronavirus drugs, which are crucial for the …
On the origins of SARS-CoV-2 main protease inhibitors
YL Janin - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
In order to address the world-wide health challenge caused by the COVID-19 pandemic, the
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …
[HTML][HTML] Crystallographic Data Collection Using a Multilayer Monochromator on an Undulator Beamline at the Shanghai Synchrotron Radiation Facility
C Zhang, Q Xu, W Wang, M Liang, L Yu, M Li, Z Zhu… - Crystals, 2024 - mdpi.com
To resolve photons hungry for weak diffraction samples by the crystallographic method, a
double-multilayer monochromator (DMM) was employed on an undulator beamline …
double-multilayer monochromator (DMM) was employed on an undulator beamline …