After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …

Autophagy, a main intracellular catabolic process, is induced in response to a variety of
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …

Cellular proteins CPSF6, NUP153 and SEC24C play crucial roles in HIV-1 infection. While
weak interactions of short phenylalanine-glycine (FG) containing peptides with isolated …

The availability of combined antiretroviral therapy (cART) has revolutionized the course of
HIV infection, suppressing HIV viremia, restoring the immune system, and improving the …

Trim-Away is a recently developed technology that exploits off-the-shelf antibodies and the
RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out rapid protein depletion …

Abstract Purpose of Review Tripartite motif (TRIM) proteins are a large group of E3 ubiquitin
ligases involved in different cellular functions. Of special interest are their roles in innate …