[HTML][HTML] Stem cells and the differentiation hierarchy in mammary gland development

NY Fu, E Nolan, GJ Lindeman… - Physiological …, 2020 - journals.physiology.org
The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Advances in ex situ tissue optical clearing

P Matryba, L Kaczmarek, J Gołąb - Laser & Photonics Reviews, 2019 - Wiley Online Library
Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Multiscale imaging of basal cell dynamics in the functionally mature mammary gland

AJ Stevenson, G Vanwalleghem… - Proceedings of the …, 2020 - National Acad Sciences
The mammary epithelium is indispensable for the continued survival of more than 5,000
mammalian species. For some, the volume of milk ejected in a single day exceeds their …

[HTML][HTML] Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

Y Han, A Villarreal-Ponce, G Gutierrez, Q Nguyen… - Cell reports, 2022 - cell.com
Maintenance of undifferentiated, long-lived, and often quiescent stem cells in the basal
compartment is important for homeostasis and regeneration of multiple epithelial tissues, but …

Embryonic mammary gland development

E Spina, P Cowin - Seminars in cell & developmental biology, 2021 - Elsevier
Embryonic mammary gland development involves the formation of mammary placodes,
invagination of flask-shaped mammary buds and development of miniature bi-layered ductal …

Developmental stage-specific distribution of macrophages in mouse mammary gland

TA Stewart, K Hughes, DA Hume… - Frontiers in Cell and …, 2019 - frontiersin.org
Mammary gland development begins in the embryo and continues throughout the
reproductive life of female mammals. Tissue macrophages (Mϕs), dependent on signals …

[HTML][HTML] An element for development: Calcium signaling in mammalian reproduction and development

TA Stewart, FM Davis - Biochimica Et Biophysica Acta (BBA)-Molecular Cell …, 2019 - Elsevier
Life begins with calcium. It is the language that a sperm cell uses to respond to instructions
from the female reproductive tract to alter its swimming pattern and gain the force required to …

The cellular organization of the mammary gland: insights from microscopy

CA Dawson, JE Visvader - Journal of Mammary Gland Biology and …, 2021 - Springer
Despite rapid advances in our knowledge of the cellular heterogeneity and molecular
regulation of the mammary gland, how these relate to 3D cellular organization remains …

Mammary mechanobiology–investigating roles for mechanically activated ion channels in lactation and involution

TA Stewart, K Hughes, AJ Stevenson… - Journal of cell …, 2021 - journals.biologists.com
The ability of a mother to produce a nutritionally complete neonatal food source has
provided a powerful evolutionary advantage to mammals. Milk production by mammary …

Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency

E Spina, J Simundza, A Incassati… - Nature …, 2022 - nature.com
Gpr125 is an orphan G-protein coupled receptor, with homology to cell adhesion and axonal
guidance factors, that is implicated in planar polarity and control of cell movements. By …