Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Emerging landscape of nanobodies and their neutralizing applications against SARS-CoV-2 virus

X Feng, H Wang - ACS Pharmacology & Translational Science, 2023 - ACS Publications
The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the
coronavirus disease 2019 (COVID-19) has significantly altered people's way of life. Despite …

Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

RS Sankhala, KG Lal, JL Jensen, V Dussupt… - Nature …, 2024 - nature.com
The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased
susceptibility to vaccine-elicited antibodies highlights the need to develop next-generation …

Revolutionizing SARS-CoV-2 omicron variant detection: Towards faster and more reliable methods

D Li, C Sun, P Zhuang, X Mei - Talanta, 2024 - Elsevier
The emergence of the highly contagious Omicron variant of SARS-CoV-2 has inflicted
significant damage during the ongoing COVID-19 pandemic. This new variant's significant …

Isolation and characterization of single domain antibodies from banded houndshark (Triakis scyllium) targeting SARS-CoV-2 spike RBD protein

WS Kim, H Do Chae, I Jung, WK Lee, WJ Lee… - Fish & Shellfish …, 2023 - Elsevier
The COVID-19 pandemic has significantly impacted human health for three years. To
mitigate the spread of SARS-CoV-2, the development of neutralizing antibodies has been …

[HTML][HTML] Revolutionizing antiviral therapy with nanobodies: Generation and prospects

MI Mustafa, A Mohammed - Biotechnology Reports, 2023 - Elsevier
As the world continues to grapple with infectious diseases, scientists are constantly
searching for effective ways to combat these deadly pathogens. One promising avenue of …

Shark IgNAR: The Next Broad Application Antibody in Clinical Diagnoses and Tumor Therapies?

X Jiang, L Sun, C Hu, F Zheng, Z Lyu, J Shao - Marine Drugs, 2023 - mdpi.com
Antibodies represent a relatively mature detection means and serve as therapeutic drug
carriers in the clinical diagnosis and treatment of cancer—among which monoclonal …

A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery

S Benjakul, AK Anthi, A Kolderup, M Vaysburd… - PNAS …, 2023 - academic.oup.com
Immunocompromised patients often fail to raise protective vaccine-induced immunity against
the global emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses

Y Yang, F Li, L Du - Journal of Nanobiotechnology, 2024 - Springer
Nanobodies, single-domain antibodies derived from variable domain of camelid or shark
heavy-chain antibodies, have unique properties with small size, strong binding affinity, easy …

Nanobodies as Diagnostic and Therapeutic Tools for Cardiovascular Diseases (CVDs)

LA Bocancia-Mateescu, D Stan, AC Mirica, MG Ghita… - Pharmaceuticals, 2023 - mdpi.com
The aim of this review is to summarize some of the most recent work in the field of
cardiovascular disease (CVD) diagnosis and therapy, focusing mainly on the role of …