Antidepressant response, the effectiveness of antidepressants in relieving symptoms of
depression, is a complex trait influenced by both genetic and environmental factors …

Major depressive disorder (MDD) is a multifactorial disease affected by several
environmental factors. Although several potential onset hypotheses have been identified …

Objective This study aimed to evaluate the effectiveness of metformin versus placebo in
overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of …

Despite numerous studies on major depressive disorder (MDD) susceptibility, the precise
underlying molecular mechanism has not been elucidated which restricts the development …

Interactions between the hypothalamic–pituitary–adrenal axis and the central 5-HT system
in the depressive state remain largely unknown. The present study investigated …

Approximately one third of individuals with major depressive disorder (MDD) do not respond
to antidepressant treatments; but what does treatment-resistant depression (TRD) mean …

Background The clinical heterogeneity in major depressive disorder (MDD), variable
treatment response, and conflicting findings limit the ability of genomics toward the discovery …

This work presents the GnG-PK/PD-AD study—a pharmacokinetics/pharmacodynamics
(PK/PD) analysis of the impact of genetic and nongenetic factors on the treatment with the …

Major depressive disorder (MDD) is a serious mental disease with negative effects on both
mental and physical health of the patient. Currently, antidepressants are among the major …

Background: Glucocorticoids are pivotal components of immunosuppressive regimens in
solid organ transplantations. This study aimed to assess the possible association between …