Evaluating intrinsic and non-intrinsic cancer risk factors

S Wu, W Zhu, P Thompson, YA Hannun - Nature communications, 2018 - nature.com
Discriminating the contribution of unmodifiable random intrinsic DNA replication errors ('bad
luck') to cancer development from those of other factors is critical for understanding cancer in …

Inflammation and liver cancer: molecular mechanisms and therapeutic targets

YM Yang, SY Kim, E Seki - Seminars in liver disease, 2019 - thieme-connect.com
Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising
from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty …

Guidelines for the use of flow cytometry and cell sorting in immunological studies*

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2017 - Wiley Online Library
From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Viral hepatitis and liver cancer

M Ringehan, JA McKeating… - … Transactions of the …, 2017 - royalsocietypublishing.org
Hepatitis B and C viruses are a global health problem causing acute and chronic infections
that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the …

Molecular mechanisms of viral oncogenesis in humans

NA Krump, J You - Nature Reviews Microbiology, 2018 - nature.com
Viral infection is a major contributor to the global cancer burden. Recent advances have
revealed that seven known oncogenic viruses promote tumorigenesis through shared host …

The role of cccDNA in HBV maintenance

L Allweiss, M Dandri - Viruses, 2017 - mdpi.com
Chronic hepatitis B virus (HBV) infection continues to be a major health burden worldwide; it
can cause various degrees of liver damage and is strongly associated with the development …

Deficient mismatch repair: read all about it

S Richman - International journal of oncology, 2015 - spandidos-publications.com
Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called
microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal cancers …

Long noncoding RNA HULC modulates the phosphorylation of YB‐1 through serving as a scaffold of extracellular signal–regulated kinase and YB‐1 to enhance …

D Li, X Liu, J Zhou, J Hu, D Zhang, J Liu, Y Qiao… - …, 2017 - Wiley Online Library
Dysregulated expression of long noncoding RNAs has been reported in many types of
cancers, indicating that it may play a critical role in tumorigenesis. The long noncoding RNA …

Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on …

S Gao, J Gang, M Yu, G Xin, H Tan - BMC cancer, 2021 - Springer
Background Liver cancer is the sixth most commonly diagnosed cancer and the fourth most
common cause of cancer death. The purpose of this work is to find new diagnostic …

Immunotherapy against cancer-related viruses

H Tashiro, MK Brenner - Cell research, 2017 - nature.com
Approximately 12% of all cancers worldwide are associated with viral infections. To date,
eight viruses have been shown to contribute to the development of human cancers …