The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Cholangiocarcinoma (CC) is the second most common tumor of the liver, originating from
the biliary system with increasing incidence and mortality worldwide. Several new …

Heterogeneity is the major challenge for cancer prevention and therapy. Here, we first
constructed high-resolution spatial transcriptomes of primary liver cancers (PLCs) containing …

Background & Aims Little is known about the metabolic regulation of cancer stem cells
(CSCs) in cholangiocarcinoma (CCA). We analyzed whether mitochondrial-dependent …

A small proportion of cancer cells that have stem cell-like properties are known as cancer
stem cells (CSCs). They can be used to identify malignant tumor phenotypes and patients …

In the last few decades, the role of cancer stem cells in initiating tumors, metastasis,
invasion, and resistance to therapies has been recognized as a potential target for tumor …

MicroRNAs (miRNAs) are a type of small non-coding RNAs that play an essential role in
numerous biological processes by regulating the post-transcriptional expression of target …

Intrahepatic cholangiocarcinoma (iCC) is a primary carcinoma of the liver with increasing
significance and major pathogenic, clinical and therapeutic challenges. Classically, it arises …

Background Liver cancer is the second most common cause of cancer-related death. Every
type of tumours including liver cancer contains cancer stem cells (CSCs). To date, the …

Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies that may develop at
any level of the biliary tree. CCA is currently classified into intrahepatic (iCCA), perihilar …