Animal models of major depression: drawbacks and challenges

B Planchez, A Surget, C Belzung - Journal of Neural Transmission, 2019 - Springer
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

The effects of psychological stress on depression

L Yang, Y Zhao, Y Wang, L Liu… - Current …, 2015 - ingentaconnect.com
Major depressive disorder is a serious mental disorder that profoundly affects an individual's
quality of life. Although the aetiologies underlying this disorder remain unclear, an …

Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties

X Zhang, L Xie, J Long, Q Xie, Y Zheng, K Liu… - Chemico-Biological …, 2021 - Elsevier
Salidroside has been identified as one of the most potent compounds isolated from various
Rhodiola plants, which have been used for a long time as adaptogens in traditional Chinese …

COVID-19 and olfactory dysfunction: a looming wave of dementia?

LM Kay - Journal of neurophysiology, 2022 - journals.physiology.org
Olfactory dysfunction is a hallmark symptom of COVID-19 disease resulting from the SARS-
CoV-2 virus. The cause of the sudden and usually temporary anosmia that most people …

[HTML][HTML] Rhodiola plants: Chemistry and biological activity

HM Chiang, HC Chen, CS Wu, PY Wu… - journal of food and drug …, 2015 - Elsevier
Rhodiola is a genus of medicinal plants that originated in Asia and Europe and are used
traditionally as adaptogens, antidepressants, and anti-inflammatory remedies. Rhodiola …

Rhodiola rosea L. as a putative botanical antidepressant

JD Amsterdam, AG Panossian - Phytomedicine, 2016 - Elsevier
Background Rhodiola rosea (R. rosea) is a botanical adaptogen with putative anti-stress
and antidepressant properties. Evidence-based data supporting the effectiveness of R …

Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea

F Limanaqi, F Biagioni, CL Busceti, M Polzella… - Antioxidants, 2020 - mdpi.com
Recent studies focused on the pharmacology and feasibility of herbal compounds as a
potential strategy to target a variety of human diseases ranging from metabolic to brain …

Pharmacological activities, mechanisms of action, and safety of salidroside in the central nervous system

Z Zhong, J Han, J Zhang, Q Xiao, J Hu… - Drug design …, 2018 - Taylor & Francis
The primary objective of this review article was to summarize comprehensive information
related to the neuropharmacological activity, mechanisms of action, toxicity, and safety of …

Traditional Chinese medicine in depression treatment: from molecules to systems

C Li, J Huang, YC Cheng, YW Zhang - Frontiers in Pharmacology, 2020 - frontiersin.org
Depression is a multigenetic or multifactorial syndrome. The central neuron system (CNS)-
orientated, single target, and conventional antidepressants are insufficient and far from …

Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway

W Tao, Y Dong, Q Su, H Wang, Y Chen, W Xue… - Behavioural Brain …, 2016 - Elsevier
Major depression is a common long-lasting or recurrent psychiatric disease with high
lifetime prevalence and high incidence of suicide. The main purpose of the current study …