Podocytes, or glomerular epithelial cells, form the final layer in the glomerular capillary wall
of the kidney. Along with the glomerular basement membrane and glomerular endothelial …

The discovery of> 60 monogenic causes of nephrotic syndrome (NS) has revealed a central
role for the actin regulators RhoA/Rac1/Cdc42 and their effectors, including the formin INF2 …

Glomerular disease is a common cause for proteinuria and chronic kidney disease leading
to end-stage renal disease requiring dialysis or kidney transplantation in children. Nephrotic …

Focal adhesions (FAs) are dynamic protein assemblies that connect cytoskeletons to the
extracellular matrix and are crucial for cell adhesion and migration. KANKs are scaffold …

Background Nephrotic syndrome is traditionally classified on the basis of the response to
standard steroid treatment. Mutations in more than 24 genes have been associated with …

Kidney ankyrin repeat–containing proteins (KANK1/2/3/4) belong to a family of scaffold
proteins, playing critical roles in cytoskeleton organization, cell polarity, and migration …

Nephrotic syndrome (NS) is relatively common in children, with most of its histological types
being minimal changed disease. Its etiology has long been attributed to lymphocyte …

Steroid-resistant nephrotic syndrome (SRNS) is a paradigmatic disease to illustrate the
major clinical consequences that can arise from genetic testing. Patients with pathogenic …

This study aimed to probe carcinogenic genes and pathways associated with Wilms' tumor
(WT) onset and malignancy progression. After screening, three datasets acquired from the …

OBJECTIVE: Kidney stone formers have a high rate of stone recurrence after kidney stone
removal surgery and there is no effective medication for treatment. Hydroxycitric acid (HCA) …