Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …

The traditional view of p53 activation includes three steps—p53 stabilization, DNA binding,
and transcriptional activation. However, recent studies indicate that each step of p53 …

Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We
used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon …

Brown adipose tissue (BAT) can disperse stored energy as heat. Promoting BAT-like
features in white adipose (WAT) is an attractive, if elusive, therapeutic approach to staunch …

The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-
dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT …

The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …

Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function
(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal …

The p53 tumor suppressor protein has well-established roles in monitoring various types of
stress signals by activating specific transcriptional targets that control cell cycle arrest and …

Disease overview Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell
lymphoproliferative disorders involving the skin, the majority of which may be classified as …

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in
TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of …