Depression is the most prevalent mental disorder in the world associated with huge socio-
economic consequences. While depressive-related symptoms are well known, the …

The COVID-19 pandemic has led to a worsening of mental health among US adults.
However, no review to date has synthesized the overall prevalence of population depressive …

Globally, too many people die prematurely from suicide and the physical comorbidities
associated with mental illness and mental distress. The purpose of this Review is to mobilise …

Depression and anxiety are the most common mental illnesses affecting children and
adolescents, significantly harming their well-being. Research has shown that regular …

Adverse childhood experiences (ACEs) and adolescent depression are both prevalent
social problems that can increase the risk of several negative health consequences …

Background Adolescent mental health is influenced by various adverse environmental
conditions. However, it remains unclear how these factors jointly affect adolescent …

Importance Adolescent major depressive disorder (MDD) is associated with serious adverse
implications for brain development and higher rates of self-injury and suicide, raising …

Inflammation is associated with poor physical and mental health including major depressive
disorder (MDD). Moreover, there is evidence that childhood adversity–a risk factor for MDD …

Diabetic patients are more affected by depression than non-diabetics, and this is related to
greater treatment resistance and associated with poorer outcomes. This increase in the …

Background Family environment and life events have long been suggested to be associated
with adolescent depression. The hippocampus plays a crucial role in the neural mechanism …