Synergy and antagonism in natural product extracts: when 1+ 1 does not equal 2
Covering: 2000 to 2019 According to a 2012 survey from the Centers for Disease Control
and Prevention, approximately 18% of the US population uses natural products (including …
and Prevention, approximately 18% of the US population uses natural products (including …
Trends in the approval of cancer therapies by the FDA in the twenty-first century
EC Scott, AC Baines, Y Gong, R Moore Jr… - Nature Reviews Drug …, 2023 - nature.com
The cancer treatment landscape has changed dramatically since the turn of the century,
resulting in substantial improvements in outcomes for patients. This Review summarizes …
resulting in substantial improvements in outcomes for patients. This Review summarizes …
High-performance self-cascade pyrite nanozymes for apoptosis–ferroptosis synergistic tumor therapy
As next-generation artificial enzymes, nanozymes have shown great promise for tumor
catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze …
catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze …
Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics
Abstract Knowledge of therapeutic targets and early drug candidates is useful for improved
drug discovery. In particular, information about target regulators and the patented …
drug discovery. In particular, information about target regulators and the patented …
Network-based prediction of drug combinations
Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an
important role in treating multiple complex diseases. Yet, our ability to identify and validate …
important role in treating multiple complex diseases. Yet, our ability to identify and validate …
Modeling polypharmacy side effects with graph convolutional networks
Motivation The use of drug combinations, termed polypharmacy, is common to treat patients
with complex diseases or co-existing conditions. However, a major consequence of …
with complex diseases or co-existing conditions. However, a major consequence of …
Molecular bottlebrush prodrugs as mono-and triplex combination therapies for multiple myeloma
Cancer therapies often have narrow therapeutic indexes and involve potentially suboptimal
combinations due to the dissimilar physical properties of drug molecules. Nanomedicine …
combinations due to the dissimilar physical properties of drug molecules. Nanomedicine …
Machine learning for integrating data in biology and medicine: Principles, practice, and opportunities
New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …
MolTrans: molecular interaction transformer for drug–target interaction prediction
Motivation Drug–target interaction (DTI) prediction is a foundational task for in-silico drug
discovery, which is costly and time-consuming due to the need of experimental search over …
discovery, which is costly and time-consuming due to the need of experimental search over …
SSI–DDI: substructure–substructure interactions for drug–drug interaction prediction
AK Nyamabo, H Yu, JY Shi - Briefings in Bioinformatics, 2021 - academic.oup.com
A major concern with co-administration of different drugs is the high risk of interference
between their mechanisms of action, known as adverse drug–drug interactions (DDIs) …
between their mechanisms of action, known as adverse drug–drug interactions (DDIs) …