Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …

The frequent occurrence of transcription and DNA replication in cells results in many
encounters, and thus conflicts, between the transcription and replication machineries. These …

R-loops have both positive and negative impacts on chromosome functions. To identify toxic
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …

The complex machineries involved in replication and transcription translocate along the
same DNA template, often in opposing directions and at different rates. These processes …

Decades of study have revealed more than 100 ribonucleoside structures incorporated as
post-transcriptional modifications mainly in tRNA and rRNA, yet the larger functional …

La was first identified as a polypeptide component of ribonucleic protein complexes targeted
by antibodies in autoimmune patients and is now known to be a eukaryote cell‐ubiquitous …

Transcription hinders replication fork progression and stability, and the Mec1/ATR
checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling …

Genomes undergo different types of sporadic alterations, including DNA damage, point
mutations, and genome rearrangements, that constitute the basis for evolution. However …

Little is known about how cells ensure DNA replication in the face of RNA polymerase II
(RNAPII)-mediated transcription, especially under conditions of replicative stress. Here we …

RNA synthesis in eukaryotes is divided among three RNA polymerases (RNAPs). RNAP III
transcribes hundreds of tRNA genes and fewer additional short RNA genes. We survey …