Autophagy mediates an amplification loop during ferroptosis

S Lee, N Hwang, BG Seok, S Lee, SJ Lee… - Cell Death & …, 2023 - nature.com
Ferroptosis, a programmed cell death, has been identified and associated with cancer and
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …

Gastric cancer: a comprehensive review of current and future treatment strategies

RE Sexton, MN Al Hallak, M Diab, AS Azmi - Cancer and Metastasis …, 2020 - Springer
Gastric cancer remains a major unmet clinical problem with over 1 million new cases
worldwide. It is the fourth most commonly occurring cancer in men and the seventh most …

Reactive oxygen species‐induced lipid peroxidation in apoptosis, autophagy, and ferroptosis

LJ Su, JH Zhang, H Gomez, R Murugan… - Oxidative medicine …, 2019 - Wiley Online Library
Reactive oxygen species‐(ROS‐) induced lipid peroxidation plays a critical role in cell death
including apoptosis, autophagy, and ferroptosis. This fundamental and conserved …

Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements

V Aggarwal, HS Tuli, A Varol, F Thakral, MB Yerer… - Biomolecules, 2019 - mdpi.com
Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

ROS induced lipid peroxidation and their role in ferroptosis

HT Endale, W Tesfaye, TA Mengstie - Frontiers in cell and …, 2023 - frontiersin.org
Reactive oxygen species (ROS) play a crucial part in the process of cell death, including
apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate …

Chronic myeloid leukemia stem cells: targeting therapeutic implications

H Mojtahedi, N Yazdanpanah, N Rezaei - Stem cell research & therapy, 2021 - Springer
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: From biology to therapeutic targeting

Y Chen, J Li, L Xu, MA Găman, Z Zou - Cell Death Discovery, 2022 - nature.com
Acute myeloid leukemia (AML) is a hematological malignancy characterized by cytogenetic
and genomic alterations. Up to now, combination chemotherapy remains the standard …

Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling

X Zhao, L Yang, N Chang, L Hou, X Zhou, L Yang… - Cell death & …, 2020 - nature.com
Inappropriate neutrophil infiltration and subsequent neutrophil extracellular trap (NET)
formation have been confirmed to be involved in chronic inflammatory conditions. Fatty liver …

Oxidative stress and ROS-mediated signaling in leukemia: novel promising perspectives to eradicate chemoresistant cells in myeloid leukemia

S Trombetti, E Cesaro, R Catapano, R Sessa… - International Journal of …, 2021 - mdpi.com
Myeloid leukemic cells are intrinsically under oxidative stress due to impaired reactive
oxygen species (ROS) homeostasis, a common signature of several hematological …

[HTML][HTML] IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+/-mice display increases atherosclerotic plaque …

S Fang, S Sun, H Cai, X Zou, S Wang, X Hao, X Wan… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Atherosclerosis plaque rupture (PR) is the pathological basis and chief culprit of
most acute cardiovascular events and death. Given the complex and important role of …