[HTML][HTML] Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy

F Bakhtiarzadeh, M Zare, Z Ghasemi… - Basic and Clinical …, 2023 - ncbi.nlm.nih.gov
A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and
social issues as a result of recurring seizures, which is regarded as a chronic brain disease …

Electrical stimulation of the piriform cortex for the treatment of epilepsy: A review of the supporting evidence

JC Young, DN Vaughan, AG Paolini, GD Jackson - Epilepsy & behavior, 2018 - Elsevier
In this review, we consider how the piriform cortex is engaged in both focal and generalized
epilepsy networks and postulate the various neural pathways that can be effectively …

Acute seizure control efficacy of multi-site closed-loop stimulation in a temporal lobe seizure model

Y Zheng, Z Jiang, A Ping, F Zhang, J Zhu… - … on Neural Systems …, 2019 - ieeexplore.ieee.org
The closed-loop electrical stimulation is emerging as a promising neural modulation therapy
for refractory epilepsy. However, the efficacy of electrical stimulation is less than optimal and …

Low-frequency stimulation inhibits epileptogenesis by modulating the early network of the limbic system as evaluated in amygdala kindling model

Y Wang, Z Xu, H Cheng, Y Guo, C Xu, S Wang… - Brain Structure and …, 2014 - Springer
Low-frequency stimulation (LFS) is emerging as a new option for the treatment of epilepsy.
The present study was designed to determine whether there is a crucial period for the …

Alpha adrenergic receptors have role in the inhibitory effect of electrical low frequency stimulation on epileptiform activity in rats

M Rezaei, N Ahmadirad, Z Ghasemi… - International Journal …, 2023 - Taylor & Francis
Aim: Low frequency stimulation (LFS) inhibits neuronal hyperexcitability following epileptic
activity. However, knowledge about LFS'inhibitory mechanisms is lacking. Here, α1 and α2 …

Pharmaco‐genetic inhibition of pyramidal neurons retards hippocampal kindling‐induced epileptogenesis

LY Chen, J Liang, F Fei, YP Ruan… - CNS neuroscience & …, 2020 - Wiley Online Library
Aims Pharmaco‐genetics emerges as a new promising approach for epileptic seizures.
Whether it can modulate epileptogenesis is still unknown. Methods Here, parvalbumin …

The subiculum and its role in focal epileptic disorders

M Lévesque, M Avoli - Reviews in the Neurosciences, 2021 - degruyter.com
The subicular complex (hereafter referred as subiculum), which is reciprocally connected
with the hippocampus and rhinal cortices, exerts a major control on hippocampal outputs …

A transient upregulation of glutamine synthetase in the dentate gyrus is involved in epileptogenesis induced by amygdala kindling in the rat

HL Sun, SH Zhang, K Zhong, ZH Xu, B Feng, J Yu… - PLoS …, 2013 - journals.plos.org
Reduction of glutamine synthetase (GS) function is closely related to established epilepsy,
but little is known regarding its role in epileptogenesis. The present study aimed to elucidate …

Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model

L Yang, Q Zhang, X Wu, X Qiu, F Fei, N Lai… - Acta Pharmacologica …, 2023 - nature.com
Cognitive deficit is a common comorbidity in temporal lobe epilepsy (TLE) and is not well
controlled by current therapeutics. How epileptic seizure affects cognitive performance …

Homeostatic activity regulation as a mechanism underlying the effect of brain stimulation

Z Chai, C Ma, X Jin - Bioelectronic Medicine, 2019 - Springer
Hyperexcitability of the neural network often occurs after brain injuries or degeneration and
is a key pathophysiological feature in certain neurological diseases such as epilepsy …