[HTML][HTML] Subicular circuit in epilepsy: deconstruct heterogeneity for precise therapeutics

Y Wang, M Liu, Q Wang - Frontiers in Neuroscience, 2023 - frontiersin.org
Temporal lobe epilepsy (TLE) is the most common form of epilepsy, accounting for more
than half of adult patients (Kanner and Bicchi, 2022). The dysfunction of the …

Consecutive 15 min is necessary for focal low frequency stimulation to inhibit amygdaloid-kindling seizures in rats

Y Liu, Y Wang, Z Xu, C Xu, X Ying, S Wang, S Zhang… - Epilepsy research, 2013 - Elsevier
Low-frequency stimulation (LFS) is emerging as a new option for the treatment of intractable
epilepsy. The stimulation duration may influence the anti-epileptic effect of LFS but is poorly …

[HTML][HTML] High capacitance freestanding PEDOT: PSS electrodes for low-frequency electric field delivery

EPW Jenkins, ST Keene, IB Dimov, P Oldroyd… - AIP Advances, 2024 - pubs.aip.org
Since the 18th century, the use of electrical stimulation has been widely used to treat
disease and control the development of cells, tissues, and organ growth. Electric fields and …

The effects of responsive and scheduled subicular high frequency stimulation in the intra-hippocampal kainic acid seizure model

L Huang, G van Luijtelaar - Epilepsy research, 2013 - Elsevier
Background Responsive stimulation is a promising and newly emerging treatment for
refractory temporal lobe epilepsy in which current is delivered to target areas following …

[HTML][HTML] Low-frequency stimulation of the primary focus retards positive transfer of secondary focus

Y Kuang, C Xu, Y Zhang, Y Wang, X Wu, Y Wang… - Scientific Reports, 2017 - nature.com
Positive transfer of secondary focus (PTS) refers to new epileptogenesis outside the primary
focus and is minimally controlled by existing treatments. Low-frequency stimulation (LFS) …

[HTML][HTML] Combination of matching responsive stimulations of hippocampus and subiculum for effective seizure suppression in temporal lobe epilepsy

F Zhang, Y Yang, Y Zheng, J Zhu, P Wang… - Frontiers in …, 2021 - frontiersin.org
Responsive neural stimulation (RNS) is considered a promising neural modulation therapy
for refractory epilepsy. Combined stimulation on different targets may hold great promise for …

Biohybrid restoration of the hippocampal loop re-establishes the non-seizing state in an in vitro model of limbic seizures

D Caron, S Buccelli, A Canal-Alonso… - Journal of Neural …, 2023 - iopscience.iop.org
Objective. The compromise of the hippocampal loop is a hallmark of mesial temporal lobe
epilepsy (MTLE), the most frequent epileptic syndrome in the adult population and the most …

New Horizons in Temporal Lobe Seizure Control

AL Velasco, PE Saucedo-Alvarado… - Journal of Clinical …, 2021 - journals.lww.com
In patients with mesial temporal lobe epilepsy, high-frequency, low-amplitude electrical
stimulation (ES) was applied during 3 weeks through contacts of intracranial electrodes that …

[HTML][HTML] 不同波形低频率电刺激对小鼠海马电点燃癫痫的作用比较

A TAO, Z XU, C WU, W Yi, W HOU… - Journal of Zhejiang …, 2015 - ncbi.nlm.nih.gov
不同波形低频率电刺激对小鼠海马电点燃癫痫的作用比较- PMC Back to Top Skip to main
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[PDF][PDF] Search for new targets of deep brain stimulation for epilepsy treatment

L Huang, E van Luijtelaar - 2016 - repository.ubn.ru.nl
Although clinical trials in refractory epilepsy are currently carried out, the field of deep brain
stimulation (DBS) in epilepsy is still at its initial stage. Little is known about where, when and …