[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

AD Gruber, TC Firsching, J Trimpert… - Veterinary …, 2022 - journals.sagepub.com
The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …

[HTML][HTML] COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbidity

K Lundstrom, A Hromić-Jahjefendić, E Bilajac… - Cellular …, 2023 - Elsevier
The COVID-19 pandemic has been the focus of research the past two years. The major
breakthrough was made by discovering pathways related to SARS-CoV-2 infection through …

SARS-CoV-2 infection increases the gene expression profile for Alzheimer's disease risk

R Green, K Mayilsamy, AR McGill, TE Martinez… - … Therapy-Methods & …, 2022 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000
infections globally thus far. Up to 30% of individuals with mild to severe disease develop …

De novo design of a stapled peptide targeting SARS-CoV-2 spike protein receptor-binding domain

R Thakkar, DK Agarwal, CB Ranaweera… - RSC Medicinal …, 2023 - pubs.rsc.org
Although effective vaccines have been developed against SARS-CoV-2, many regions in
the world still have low rates of vaccination and new variants with mutations in the viral spike …

SARS-CoV-2-induced gut microbiome dysbiosis: Implications for colorectal cancer

MC Howell, R Green, AR McGill, R Dutta, S Mohapatra… - Cancers, 2021 - mdpi.com
Simple Summary Specific guidance regarding cancer treatment in coronavirus disease-19
(COVID-19) patients is lacking due to minimal knowledge. It has been observed that patients …

[HTML][HTML] Molecular mechanisms involved in pathogenicity of SARS-CoV-2: Immune evasion and implications for therapeutic strategies

H Latifi-Pupovci - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the outbreak of
unusual viral pneumonia that emerged in late 2019 in the city of Wuhan, China. Since then …

SARS-CoV-2-associated gut microbiome alteration; A new contributor to colorectal cancer pathogenesis

SA Mozaffari, A Salehi, E Mousavi, BA Zaman… - … -Research and Practice, 2022 - Elsevier
The emergence of a novel coronavirus, COVID-19, in December 2019 led to a global
pandemic with more than 170 million confirmed infections and more than 6 million deaths …

Gastrointestinal microbiota dysbiosis associated with SARS-CoV-2 infection in colorectal cancer: the implication of probiotics

F Odun-Ayo, L Reddy - Gastroenterology Insights, 2022 - mdpi.com
The complexity of coronavirus disease 2019 (COVID-19)'s pathophysiology is such that
microbial dysbiosis in the lung and gastrointestinal (GI) microbiota may be involved in its …

SOS1-inspired hydrocarbon-stapled peptide as a pan-Ras inhibitor

A Li, X Li, J Zou, X Zhuo, S Chen, X Chai, C Gai… - Bioorganic …, 2023 - Elsevier
Blocking the interaction between Ras and Son of Sevenless homolog 1 (SOS1) has been an
attractive therapeutic strategy for treating cancers involving oncogenic Ras mutations. K-Ras …