The link between cancer metabolism and immunosuppression, inflammation and immune
escape has generated major interest in investigating the effects of low pH on tumor …

The immune system exists in a delicate equilibrium between inflammatory responses and
tolerance. This unique feature allows the immune system to recognize and respond to …

The complexity of the tumor immunoenvironment is underscored by the emergence and
discovery of different subsets of immune effectors and regulatory cells. Tumor-induced …

Dendritic cells (DC) play unique and diverse roles in the tumor occurrence, development,
progression and response to therapy. First of all, DC can actively uptake tumor-associated …

The incidence of liver cancer is continuously rising where hepatocellular carcinoma (HCC)
remains the most common form of liver cancer accounting for approximately 80–90% of the …

Bone metastasis is associated with significant morbidity for cancer patients and results in a
reduced quality of life. The bone marrow is a fertile soil containing a complex composition of …

Myeloid cells play a key role in the outcome of anti-tumor immunity and response to anti-
cancer therapy, since in the tumor microenvironment they may exert both stimulatory and …

Tumor progression has been demonstrated to be supported by chronic inflammatory
conditions developed in the tumor microenvironment and characterized by the long-term …

Malignant melanoma is characterized by a rapid progression, metastasis to distant organs,
and resistance to chemo-and radiotherapy. Well-defined immunogenic capacities of …

Immune effector and regulatory cells in the tumor microenvironment are key factors in tumor
development and progression as the pathogenesis of cancer vitally depends on the …