Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions

G Cheng, W Sa, C Cao, L Guo, H Hao, Z Liu… - Frontiers in …, 2016 - frontiersin.org
Quinoxaline 1, 4-di-N-oxides (QdNOs) have manifold biological properties, including
antimicrobial, antitumoral, antitrypanosomal and antiinflammatory/antioxidant activities …

Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

OO Ajani - European journal of medicinal chemistry, 2014 - Elsevier
Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide
biological properties and diverse therapeutic applications in medicinal research. They are …

Novel antimalarial chloroquine-and primaquine-quinoxaline 1, 4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity …

L Bonilla-Ramirez, A Rios, M Quiliano… - European Journal of …, 2018 - Elsevier
Emergence of drug resistance and targeting all stages of the parasite life cycle are currently
the major challenges in antimalarial chemotherapy. Molecular hybridization combining two …

Quinoxaline 1, 4-dioxides: advances in chemistry and chemotherapeutic drug development

GI Buravchenko, AE Shchekotikhin - Pharmaceuticals, 2023 - mdpi.com
N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse
biological properties. The high reactivity and tendency to undergo various rearrangements …

In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-N-oxide Derivatives against Trypanosoma cruzi as Trypanothione …

A González-González, O Sánchez-Sánchez… - International Journal of …, 2022 - mdpi.com
American trypanosomiasis is a worldwide health problem that requires attention due to
ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1 …

Recent advances in design of potential quinoxaline anti-infectives

J Jampilek - Current medicinal chemistry, 2014 - ingentaconnect.com
Antimicrobial diazanaphthalenes are indispensable in the treatment of various infections.
The quinoxaline scaffold possesses unique physicochemical properties and provides a …

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

KF Chacón-Vargas, B Nogueda-Torres… - Molecules, 2017 - mdpi.com
Chagas disease or American trypanosomiasis is a worldwide public health problem. In this
work, we evaluated 26 new propyl and isopropyl quinoxaline-7-carboxylate 1, 4-di-N-oxide …

Anchoring of a nickel Schiff base complex with mixed ligands on MCM-41 as a heterogeneous catalyst for the synthesis of quinoxaline derivatives by various energies

M Bharathi, S Mathivathani, S Indira, G Vinoth… - Polyhedron, 2023 - Elsevier
A new class of heterogeneous catalyst, a nickel Schiff base complex of mixed ligands on
MCM-41, has been synthesized. The Ni-MCM-41 catalyst has been characterized by FT-IR …

Isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives induce regulated necrosis-like cell death on Leishmania (Leishmania) mexicana

KF Chacón-Vargas, S Andrade-Ochoa… - Parasitology …, 2018 - Springer
Leishmaniasis is a neglected tropical disease caused by the parasite of the genus
Leishmania. About 13 million people are infected worldwide, and it is estimated that 350 …

Quinoxaline and quinoxaline‐1,4‐di‐N‐oxides: An emerging class of antimycobacterials

RS Keri, SS Pandule, S Budagumpi… - Archiv der …, 2018 - Wiley Online Library
Tuberculosis (TB) is a highly dreaded, infectious, chronic, airborne disease affecting more
than two million people all around the world, with more than eight million cases every …