Infections at the maternal–fetal interface: an overview of pathogenesis and defence

CJ Megli, CB Coyne - Nature Reviews Microbiology, 2022 - nature.com
Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …

Pathogenesis of viral infections during pregnancy

PS Creisher, SL Klein - Clinical Microbiology Reviews, 2024 - Am Soc Microbiol
Viral infections during pregnancy are associated with significant adverse perinatal and fetal
outcomes. Pregnancy is a unique immunologic and physiologic state, which can influence …

Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation

HL Zhu, LM Dai, YW Xiong, XT Shi, WB Liu… - Journal of Hazardous …, 2022 - Elsevier
Heavy metal cadmium (Cd), a classical environmental pollutant, causes placental apoptosis
and fetal growth restriction (FGR), whereby the mechanism remains unclear. Here, our …

Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

L Yang, EC Semmes, C Ovies, C Megli, S Permar… - Elife, 2022 - elifesciences.org
Infections at the maternal-fetal interface can directly harm the fetus and induce complications
that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived …

Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice

PS Creisher, MA Parish, J Lei, J Liu, JL Perry… - Mbio, 2024 - Am Soc Microbiol
Influenza A virus infection during pregnancy can cause adverse maternal and fetal
outcomes but the mechanism responsible remains elusive. Infection of outbred mice with …

Cytomegalovirus and pregnancy: a narrative review

KFM Pontes, LMM Nardozza, AB Peixoto… - Journal of Clinical …, 2024 - mdpi.com
Cytomegalovirus (CMV) infection is the most common congenital infection worldwide,
affecting between 0.7% and 1% of all live births. Approximately 11% of infected newborns …

Host-viral interactions at the maternal-fetal interface. What we know and what we need to know

JH Girsch, MC Mejia Plazas, A Olivier, M Farah… - Frontiers in …, 2022 - frontiersin.org
In humans, the hemochorial placenta is a unique temporary organ that forms during
pregnancy to support fetal development, gaseous exchange, delivery of nutrition, removal of …

Immune prophylaxis and therapy for human cytomegalovirus infection

EB Struble, H Murata, T Komatsu, D Scott - International Journal of …, 2021 - mdpi.com
Human Cytomegalovirus (HCMV) infection is widespread and can result in severe sequelae
in susceptible populations. Primary HCMV infection of naïve individuals results in life-long …

The Interactive Complex between Cytomegalovirus Kinase vCDK/pUL97 and Host Factors CDK7–Cyclin H Determines Individual Patterns of Transcription in Infected …

M Schütz, A Cordsmeier, C Wangen, AHC Horn… - International Journal of …, 2023 - mdpi.com
The infection of human cytomegalovirus (HCMV) is strongly determined by the host–cell
interaction in a way that the efficiency of HCMV lytic replication is dependent on the …

Fetal Liver Volume Assessment Using Magnetic Resonance Imaging in Fetuses With Cytomegalovirus Infection

A Hawkins-Villarreal, AL Moreno-Espinosa… - Frontiers in …, 2022 - frontiersin.org
Objective To assess fetal liver volume (FLV) by magnetic resonance imaging (MRI) in
cytomegalovirus (CMV)-infected fetuses compared to a group of healthy fetuses. Method …