The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer

B Shi, WW Liu, K Yang, GM Jiang, H Wang - Molecular Cancer, 2022 - Springer
Gastrointestinal cancer is the most common human malignancy characterized by high
lethality and poor prognosis. Emerging evidences indicate that N6-methyladenosine (m6A) …

The potential role of m6A RNA methylation in the aging process and aging-associated diseases

J Sun, B Cheng, Y Su, M Li, S Ma, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA
modification. m6A modification is a dynamic and reversible post-transcriptional regulatory …

RNA modifications in cardiovascular health and disease

A Gatsiou, K Stellos - Nature Reviews Cardiology, 2023 - nature.com
RNA is not always a faithful copy of DNA. Advances in tools enabling the interrogation of the
exact RNA sequence have permitted revision of how genetic information is transferred. We …

[HTML][HTML] N6-methyladenosine RNA methylation in cardiovascular diseases

C Liu, L Gu, W Deng, Q Meng, N Li, G Dai… - Frontiers in …, 2022 - frontiersin.org
N6‑methyladenosine (m6A) modification is the most universal and abundant post-
transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR …

RNA methylation and cellular response to oxidative stress-promoting anticancer agents

M Ponzetti, N Rucci, S Falone - Cell Cycle, 2023 - Taylor & Francis
Disruption of the complex network that regulates redox homeostasis often underlies resistant
phenotypes, which hinder effective and long-lasting cancer eradication. In addition, the RNA …

Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases

V Sikorski, A Vento, E Kankuri - Molecular Therapy-Nucleic Acids, 2022 - cell.com
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …

[HTML][HTML] N6-methyladenosine (m6A) RNA modification in the pathophysiology of heart failure: a narrative review

S Liu, T Wang, Z Cheng, J Liu - Cardiovascular Diagnosis and …, 2022 - ncbi.nlm.nih.gov
Methods We searched related literature using the keywords: m6A AND heart failure in
PubMed, Web of Science and Medline. The language was confined to English. The …

N (6)-methyladenosine modification: a vital role of programmed cell death in myocardial ischemia/reperfusion injury

J Wang, Y Li, S Zhang - International Journal of Cardiology, 2022 - Elsevier
Abstract N (6)-methyladenosine (m 6 A) modification is closely associated with myocardial
ischemia/reperfusion injury (MIRI). As the most common modification among RNA …

WTAP-mediated m6A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis

X An, R Wang, Z Lv, W Wu, Z Sun, R Wu… - … & Molecular Medicine, 2024 - nature.com
Osteoarthritis (OA) is the most common form of arthritis. However, the exact pathogenesis
remains unclear. Emerging evidence shows that N6-methyladenosine (m6A) modification …

[HTML][HTML] Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m6A modification of Trio mRNA

J Li, J Chen, M Zhao, Z Li, N Liu, H Fang… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background The modification of N 6-methyladenosine (m 6 A) is a dynamic and reversible
course that might play a role in cardiovascular disease. However, the mechanisms of m 6 A …