COVID-19 in pregnancy: implications for fetal brain development

LL Shook, EL Sullivan, JO Lo, RH Perlis… - Trends in molecular …, 2022 - cell.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
during pregnancy on the developing fetal brain is poorly understood. Other antenatal …

SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental disorders

H Dubey, RK Sharma, S Krishnan… - Frontiers in …, 2022 - frontiersin.org
Pregnant women constitute one of the most vulnerable populations to be affected by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the cause of coronavirus …

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

F Sauve, S Nampoothiri, SA Clarke, D Fernandois… - …, 2023 - thelancet.com
Background We have recently demonstrated a causal link between loss of gonadotropin-
releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive …

Pathogenic infections during pregnancy and the consequences for fetal brain development

S Jash, S Sharma - Pathogens, 2022 - mdpi.com
Pathogens comprised of viruses, bacteria, gut microbiome, and parasites are a leading
cause of ever-emerging diseases in humans. Studying pathogens for their ability to cause …

Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for …

F Pistollato, M Petrillo, LA Clerbaux, G Leoni… - Reproductive …, 2022 - Elsevier
The possible neurodevelopmental consequences of SARS-CoV-2 infection are presently
unknown. In utero exposure to SARS-CoV-2 has been hypothesized to affect the developing …

The adverse outcome pathway framework applied to neurological symptoms of COVID-19

HT Hogberg, A Lam, E Ohayon, MA Shahbaz… - Cells, 2022 - mdpi.com
Several reports have shown that the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has the potential to also be neurotropic. However, the mechanisms by which …

Schizophrenia animal modeling with epidermal growth factor and its homologs: Their connections to the inflammatory pathway and the dopamine system

H Sotoyama, H Namba, M Tohmi, H Nawa - Biomolecules, 2023 - mdpi.com
Epidermal growth factor (EGF) and its homologs, such as neuregulins, bind to ErbB (Her)
receptor kinases and regulate glial differentiation and dopaminergic/GABAergic maturation …

Fetal brain damage during maternal COVID-19: emerging hypothesis, mechanism, and possible mitigation through maternal-targeted nutritional supplementation

C Germano, A Messina, E Tavella, R Vitale, V Avellis… - Nutrients, 2022 - mdpi.com
The recent outbreak of the novel Coronavirus (SARS-CoV-2 or CoV-2) pandemic in 2019
and the risk of CoV-2 infection during pregnancy led the scientific community to investigate …

Prenatal SARS-CoV-2 Spike Protein Exposure Induces Autism-Like Neurobehavioral Changes in Male Neonatal Rats

MA Erdogan, M Turk, GD Doganay, IH Sever… - Journal of Neuroimmune …, 2023 - Springer
Recent research on placental, embryo, and brain organoids suggests that the COVID-19
virus may potentially affect embryonic organs, including the brain. Given the established link …

[HTML][HTML] Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy

D Alves de Araujo Junior, F Motta… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2 infection and perinatal neurological outcomes are still not completely
understood. However, there is recent evidence of white matter disease and impaired …