Transcriptional activation of erythropoietin, glycolytic enzymes, and vascular endothelial
growth factor occurs during hypoxia or in response to cobalt chloride (CoCl2) in Hep3B …

Endogenously produced pro-oxidant reactive species are essential to life, being involved in
several biological functions. However, when overproduced (eg due to exogenous …

Lipid peroxidation is a well known example of oxidative damage in cell membranes,
lipoproteins, and other lipid-containing structures. Peroxidative modification of unsaturated …

Apoptosis or programmed cell death, is essential for the normal functioning and survival of
most multi-cellular organisms. The morphological and biochemical characteristics of …

Nitric oxide (NO) and reactive oxygen species exert multiple modulating effects on
inflammation and play a key role in the regulation of immune responses. They affect virtually …

Quinones represent a class of toxicological intermediates which can create a variety of
hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis …

Oxidative stress is associated with the pathogenesis of hypertension. Decreased
bioavailability of nitric oxide (NO) is one of the mechanisms involved in the pathogenesis. It …

The metal chelating properties of flavonoids suggest that they may play a role in metal-
overload diseases and in all oxidative stress conditions involving a transition metal ion. A …

Hydrogen peroxide (H2O2) belongs to the reactive oxygen species (ROS), known as
oxidants that can react with various cellular targets thereby causing cell damage or even cell …

Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …