It has been known that glutathione S-transferases (GSTs) can reduce lipid hydroperoxides
through their Se-independent glutathione peroxidase activity and that these enzymes can …

Обобщены литературные данные, отражающие роль активных форм кислорода (АФК)
в качестве вторичных посредников в процессах жизнедеятельности клеток. АФК …

To test whether the antiapoptotic protein Bcl-2 prevents apoptosis and injury of
cardiomyocytes after ischemia-reperfusion (I/R), we generated a line of transgenic mice that …

The oxidation hypothesis proposes that low density lipoprotein must be oxidatively modified
to trigger the pathological events of atheroscleosis. In this article, we evaluate recent studies …

During normal cellular metabolism, mitochondrial electron transport results in the formation
of superoxide anion (O⨪ 2) and subsequently hydrogen peroxide (H 2 O 2). Because H 2 O …

In this review the development of the concept 'hypoxia-reoxygenation injury'is outlined. An
update of some important factors and mechanisms related to oxidative stress injury in …

Glutamine is a multifaceted amino acid used for hepatic urea synthesis, renal
ammoniagenesis, gluconeogenesis in both liver and kidney, and as a major respiratory fuel …

Reactive oxygen species (ROS) are thought to have effects on T-cell function and
proliferation. Low concentrations of ROS in T cells are a prerequisite for cell survival, and …

The insulin signaling pathway is activated by tyrosine phosphorylation of the insulin receptor
and key post-receptor substrate proteins and balanced by the action of specific protein …

Background—We recently identified agonistic autoantibodies directed against the
angiotensin AT1 receptor (AT1-AA) in the plasma of preeclamptic women. To elucidate their …