Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked
to type 2 diabetes and obesity, identified> 20 associated loci. However, most loci were …

Causal gene discovery methods are often evaluated using gold-standard (GS) sets of causal
genes. However, GS gene sets are always incomplete, leading to mis-estimation of …

The dysregulation of regulatory mechanisms due to Single Nucleotide Polymorphisms
(SNPs) can lead to diseases and does not affect all cell (sub) types equally. Current …

Genomic biobanks provide valuable resources for studying how genetic variation affects
phenotypic differences and disease susceptibility, driving advancements in human health …

Background: While recent sequencing studies have revealed that 10% of childhood gliomas
are caused by rare germline mutations, the role of common variants is undetermined and no …

In the field of complex genetics, the use of genome wide association studies (GWAS) to
discover genetic variants associated with complex traits and disease has been extremely …

In genetic studies, understanding the genetic basis underlying complex traits takes center
stage. Modern high-throughput technologies have empowered researchers to generate …

Systematic assessment of the genetic architecture of type 2 diabetes (T2D) has allowed the
identification of hundreds of genetic loci contributing to T2D risk. However, understanding …

A large proportion of genetic variations involved in complex diseases are rare and located
within non-coding regions, making the interpretation of underlying biological mechanisms a …

La sepsis es un proceso patológico de respuesta desregulada a una infección. Los casos
graves de sepsis pueden desembocar en shock séptico, que se relaciona con una elevada …