Research over the past several decades has unmasked a major contribution of disrupted
chromatin regulatory processes to human disease, particularly cancer. Advances in genome …

There is growing evidence of the presence of cancer stem cells in urothelial carcinoma.
Cancer stem cells have the ability to self‐renew and to differentiate into all cell types of the …

Abstract microRNAs (miRNAs) can be delivered to tumor cells where they exert their function
via mesenchymal stem cells (MSCs)-derived exosomes. This study investigated exosomal …

Abstract Long noncoding RNA 19 (H19) has been shown to promote bladder cancer cell
proliferation and metastasis. However, little is known about how miR-675, mature product of …

Betulinic acid (BA), a pentacyclic triterpenoid isolated from tree bark, exhibits antitumor
effects against solid malignancies and triggers autophagy and/or apoptosis in human cancer …

BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data
support a role of BMI1 in cancer. The central domain of BMI1 is involved in protein–protein …

Glioblastomas (GBM s) are the most common of both benign and malignant primary brain
tumours, in which the inflammatory and immunologic abnormalities are involved. Interleukin …

MicroRNAs (miRNAs) are recognized as important molecules and have emerged as
important gene regulators in tumorigenesis. Growing evidence suggested that miR-218 was …

Abstract RNF144A is a DNA damage-induced E3 ubiquitin ligase that targets proteins
involved in genome instability for degradation, eg, DNA-PKcs and BMI1. RNF144A is …

Background The epithelial-to-mesenchymal transition (EMT) is a critical step in tumor
metastasis. CAV-1 has been shown to be an oncogene in bladder cancer. However, little is …