Organoids are biomimetic tissue analogs that are generated via the self‐organization of
stem cells or adult cells relying on developmental biology principles. They present tissue …

The human cardiac organoid (hCO) is three-dimensional tissue model that is similar to an in
vivo organ and has great potential on heart development biology, disease modeling, drug …

Despite the advances in treatment options, cardiovascular disease (CVDs) remains the
leading cause of death over the world. Chronic inflammatory response and irreversible …

Proper placental development in early pregnancy ensures a positive outcome later on. The
developmental relationship between the placenta and embryonic organs, such as the heart …

Heart disease involves irreversible myocardial injury that leads to high morbidity and
mortality rates. Numerous cell-based cardiac in vitro models have been proposed as …

Cardiac organoids are in vitro self-organizing and three-dimensional structures composed of
multiple cardiac cells (ie, cardiomyocytes, endothelial cells, cardiac fibroblasts, etc.) with or …

During the last decades, hiPSC-derived organoids have been extensively studied and used
as in vitro models for several applications among which research studies. They can be …

The human heart lacks significant regenerative capacity; thus, the solution to heart failure
(HF) remains organ donation, requiring surgery and immunosuppression. The demand for …

The generation of mature and vascularized human pluripotent stem cell-derived cardiac
organoids (hPSC-COs) is necessary to ensure the validity of drug screening and disease …

Despite enormous advances in the generation of organoids, robust and stable protocols of
organoids are still a major challenge to researchers. Research for assessing structures of …