Background The retrograde endocannabinoid (eCB) pathway is closely associated with the
etiology of major depressive disorder (MDD) at both pathophysiological and genetic levels …

Prenatal alcohol exposure (PAE) occurs in~ 11% of North American pregnancies and is the
most common known cause of neurodevelopmental disabilities such as fetal alcohol …

Depression is a common, recurrent mental disorder and one of the leading causes of
disability and global burden of disease worldwide. Up to 15%-40% of cases do not respond …

Background Peer victimisation has been associated with depressive symptoms during
adolescence, however not all peer victimised adolescents will exhibit such symptoms. This …

Background DNA methylation as a biomarker is well suited to investigate dynamic
processes, such as symptom improvement. For this study we focus on epigenomic state or …

In recent years, evidence has accumulated with regard to the ubiquity of pleiotropy across
the genome, and shared genetic etiology is thought to play a large role in the widespread …

Objective With its high prevalence, depression's pathogenesis remains unclear. Recent
attention has turned to the interplay between depression and epigenetic modifications …

Baicalin (BA), a flavonoid glycoside extracts from Scutellaria baicalensis Georgi, has been
reported to exert antidepressant effects. Emerging evidence indicates that neuronal …

Preterm birth is a biological risk factor for developmental problems. Infants born preterm are
more likely to present difficulties and potential delays in all areas of development. The aim of …

Background Childhood obesity is associated with adult major depressive disorder (MDD),
but their causality is not clear. Methods We performed a two‐sample Mendelian …