The needle in the haystack: Identifying and validating common genes of depression, insomnia, and inflammation
J Mei, Y Wang, X Song, X Xie, G Wang, C Chen… - Journal of Affective …, 2023 - Elsevier
Background Insomnia, inflammation, and depression are often co-occurring conditions. The
mechanisms underlying these conditions remain unclear. Materials and methods We …
mechanisms underlying these conditions remain unclear. Materials and methods We …
[HTML][HTML] The diagnostic utility of miRNA and elucidation of pathological mechanisms in major depressive disorder
CSH Ho, MWT Soh, GWN Tay - Comprehensive Psychiatry, 2023 - Elsevier
Aims Our study aims to explore how miRNAs can elucidate the molecular mechanisms of
major depressive disorder (MDD) by comparing the miRNA levels in the blood serum of …
major depressive disorder (MDD) by comparing the miRNA levels in the blood serum of …
Complex Intersections Between Adverse Childhood Experiences and Negative Life Events Impact the Phenome of Major Depression
A Vasupanrajit, M Maes, K Jirakran… - Psychology Research …, 2024 - Taylor & Francis
Background There is evidence that adverse childhood experiences (ACEs) and negative life
events (NLEs) are associated with major depression (MDD). Purpose To determine whether …
events (NLEs) are associated with major depression (MDD). Purpose To determine whether …
[HTML][HTML] Longitudinal early epigenomic signatures inform molecular paths of therapy response and remission in depressed patients
E Van Assche, C Hohoff, J Zang… - Frontiers in Molecular …, 2023 - ncbi.nlm.nih.gov
Methods We used data from a randomized controlled trial (RCT) with MDD patients (N= 112)
receiving a cognitive intervention. At baseline and 8 weeks, blood for DNA methylation …
receiving a cognitive intervention. At baseline and 8 weeks, blood for DNA methylation …
[HTML][HTML] Region-specific microRNA alterations in marmosets carrying SLC6A4 polymorphisms are associated with anxiety-like behavior
N Popa, D Bachar, AC Roberts, AM Santangelo… - …, 2022 - thelancet.com
Background Psychiatric diseases such as depression and anxiety are multifactorial
conditions, highly prevalent in western societies. Human studies have identified a number of …
conditions, highly prevalent in western societies. Human studies have identified a number of …
Risk factors of chronic course of anxiety and depressive disorders: a 3-year longitudinal study in the general population
KCP Remmerswaal, M Ten Have, R de Graaf… - Social psychiatry and …, 2023 - Springer
Background Risk factors of a chronic course of anxiety and depressive disorders were
previously studied using a limited definition of recovery, ie remission of the index disorder …
previously studied using a limited definition of recovery, ie remission of the index disorder …
[PDF][PDF] Identification of a strong genetic risk factor for major depressive disorder in the human virome
N Kobayashi, K Shimada, A Ishii, R Osaka… - Iscience, 2024 - cell.com
The heritability of major depressive disorder (MDD) is reportedly 30-50%. However, the
genetic basis of its heritability remains unknown. Within SITH-1, a risk factor for MDD in …
genetic basis of its heritability remains unknown. Within SITH-1, a risk factor for MDD in …
[HTML][HTML] Unravelling robust brain-behavior links of depressive complaints through granular network models for understanding heterogeneity
Background Depressive symptoms are highly prevalent, present in heterogeneous symptom
patterns, and share diverse neurobiological underpinnings. Understanding the links …
patterns, and share diverse neurobiological underpinnings. Understanding the links …
Genome-wide association studies on Northern Italy isolated populations provide further support concerning genetic susceptibility for major depressive disorder
V Dattilo, S Ulivi, A Minelli, M La Bianca… - The World Journal of …, 2023 - Taylor & Francis
Objectives Major depressive disorder (MDD) is a psychiatric disorder with pathogenesis
influenced by both genetic and environmental factors. To date, the molecular-level …
influenced by both genetic and environmental factors. To date, the molecular-level …
[HTML][HTML] Exploring the similarities between risk factors triggering depression in humans and elevated in-cage “inactive but awake” behavior in laboratory mice
O Schmitt, E Finnegan, A Trevarthen… - Frontiers in Veterinary …, 2024 - frontiersin.org
Introduction Depression is a human mental disorder that can also be inferred in non-human
animals. This study explored whether time spent inactive but awake (“IBA”) in the home …
animals. This study explored whether time spent inactive but awake (“IBA”) in the home …