[HTML][HTML] Common human genetic variants of APOE impact murine COVID-19 mortality
BN Ostendorf, MA Patel, J Bilanovic, HH Hoffmann… - Nature, 2022 - nature.com
Clinical outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2) infection are highly
heterogeneous, ranging from asymptomatic infection to lethal coronavirus disease 2019 …
heterogeneous, ranging from asymptomatic infection to lethal coronavirus disease 2019 …
[HTML][HTML] Dissecting human population variation in single-cell responses to SARS-CoV-2
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …
the genetic and immunological basis of which has begun to be deciphered. However, the …
[HTML][HTML] Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study
Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …
[HTML][HTML] A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
SARS-CoV-2 infections display tremendous interindividual variability, ranging from
asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies …
asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies …
[HTML][HTML] Increased risk of severe clinical course of COVID-19 in carriers of HLA-C* 04: 01
Background Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic,
there has been increasing urgency to identify pathophysiological characteristics leading to …
there has been increasing urgency to identify pathophysiological characteristics leading to …
[PDF][PDF] Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
JA Kosmicki, JE Horowitz, N Banerjee, R Lanche… - The American Journal of …, 2021 - cell.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We …
disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We …
Novel genes and sex differences in COVID-19 severity
R Cruz, S Diz-de Almeida… - Human Molecular …, 2022 - academic.oup.com
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus
disease 2019 (COVID-19) positive cases with an extensive clinical information that were …
disease 2019 (COVID-19) positive cases with an extensive clinical information that were …
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene
Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …
Bidirectional causal associations between type 2 diabetes and COVID‐19
H Cao, A Baranova, X Wei, C Wang… - Journal of Medical …, 2023 - Wiley Online Library
Observational studies have reported high comorbidity between type 2 diabetes (T2D) and
severe COVID‐19. However, the causality between T2D and COVID‐19 has yet to be …
severe COVID‐19. However, the causality between T2D and COVID‐19 has yet to be …
HumanNet v3: an improved database of human gene networks for disease research
Network medicine has proven useful for dissecting genetic organization of complex human
diseases. We have previously published HumanNet, an integrated network of human genes …
diseases. We have previously published HumanNet, an integrated network of human genes …