[HTML][HTML] The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

QS Wang, R Edahiro, H Namkoong… - Nature …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease
that has caused millions of deaths, where comprehensive understanding of disease …

[HTML][HTML] Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19

H Abolhassani, S Delavari, N Landegren… - Journal of Allergy and …, 2022 - Elsevier
Background Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected
individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the …

Genetic mechanisms of COVID-19 and its association with smoking and alcohol consumption

S Rao, A Baranova, H Cao, J Chen… - Briefings in …, 2021 - academic.oup.com
We aimed to investigate the genetic mechanisms associated with coronavirus disease of
2019 (COVID-19) outcomes in the host and to evaluate the possible associations between …

[HTML][HTML] Genome-wide association study of hospitalized COVID-19 patients in the United Arab Emirates

M Mousa, H Vurivi, H Kannout, M Uddin, N Alkaabi… - …, 2021 - thelancet.com
Background The heterogeneity in symptomatology and phenotypic profile attributable to
COVID-19 is widely unknown. The objective of this manuscript is to conduct a trans-ancestry …

VannoPortal: multiscale functional annotation of human genetic variants for interrogating molecular mechanism of traits and diseases

D Huang, Y Zhou, X Yi, X Fan, J Wang… - Nucleic acids …, 2022 - academic.oup.com
Interpreting the molecular mechanism of genomic variations and their causal relationship
with diseases/traits are important and challenging problems in the human genetic study. To …

[HTML][HTML] Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection

J Hou, Y Wei, J Zou, R Jaffery, L Sun, S Liang… - Nature …, 2024 - nature.com
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely
unknown due to the biases of previous large-scale studies toward pro-viral host factors. To …

[HTML][HTML] COVID-19-related ARDS: key mechanistic features and treatments

J Selickman, CS Vrettou, SD Mentzelopoulos… - Journal of clinical …, 2022 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome historically
characterized by the presence of severe hypoxemia, high-permeability pulmonary edema …

[HTML][HTML] Circulating polyunsaturated fatty acids and COVID-19: a prospective cohort study and Mendelian randomization analysis

Y Sun, R Chatterjee, A Ronanki, K Ye - Frontiers in Medicine, 2022 - frontiersin.org
Higher circulating polyunsaturated fatty acids (PUFAs), especially omega-3 fatty acids, have
been linked to a better prognosis in patients of coronavirus disease 2019 (COVID-19) …

[HTML][HTML] Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP …

D Gemmati, G Longo, I Gallo, JA Silva… - Frontiers in …, 2022 - frontiersin.org
Background: Development and worldwide availability of safe and effective vaccines against
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to fight severe symptoms of …

[PDF][PDF] Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity

S Zhang, J Cooper-Knock, AK Weimer, M Shi… - Cell systems, 2022 - cell.com
The determinants of severe COVID-19 in healthy adults are poorly understood, which limits
the opportunity for early intervention. We present a multiomic analysis using machine …