Inhibition of SGLT2 co-transporter by dapagliflozin ameliorates tubular proteinuria and tubule-interstitial injury at the early stage of diabetic kidney disease
Diabetic kidney disease (DKD) is characterized by progressive impairment of kidney
function. It has been postulated that tubule-interstitial injury, associated with tubular …
function. It has been postulated that tubule-interstitial injury, associated with tubular …
Potential Medicinal Value of Rhein for Diabetic Kidney Disease
X Mao, D Xu, S Yue, R Fu, S Zhang, Y Tang - Chinese Journal of …, 2023 - Springer
Diabetic kidney disease (DKD) is the primary cause of mortality among diabetic patients.
With the increasing prevalence of diabetes, it has become a major concern around the …
With the increasing prevalence of diabetes, it has become a major concern around the …
Lupenone improves type 2 diabetic nephropathy by regulating NF-κB pathway-mediated inflammation and TGF-β1/Smad/CTGF-associated fibrosis
H Wu, F Xu, X Huang, X Li, P Yu, L Zhang, X Yang… - Phytomedicine, 2023 - Elsevier
Background Type 2 diabetic nephropathy is a common diabetic complication and the main
cause of death in patients with diabetes. Research has aimed to find an ideal drug with …
cause of death in patients with diabetes. Research has aimed to find an ideal drug with …
Insights into the Therapeutic Potential of Phytoconstituents as an Epigenetic Modulators in Diabetic Nephropathy
Chronic diabetes is commonly associated with the development of nephropathy, which is a
prevalent complication. Hyperglycemia is believed to initiate various biochemical …
prevalent complication. Hyperglycemia is believed to initiate various biochemical …
[HTML][HTML] DNA methylation enzymes in the kidneys of male and female BTBR ob/ob mice
BM Veloso Pereira, M Charleaux de Ponte… - Frontiers in …, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is the leading cause of the end-stage renal disease. Recent
studies have shown that epigenetic modifications contribute to alterations in gene …
studies have shown that epigenetic modifications contribute to alterations in gene …
Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution
L Luo, S Wang, Y Hu, L Wang, X Jiang, J Zhang, X Liu… - ACS …, 2023 - ACS Publications
Macrophages are central to the pathogenesis of kidney disease and serve as an effective
therapeutic target for kidney injury and fibrosis. Among them, M2-type macrophages have …
therapeutic target for kidney injury and fibrosis. Among them, M2-type macrophages have …
[HTML][HTML] Regulation of renal lipid deposition in diabetic nephropathy on morroniside via inhibition of NF-KB/TNF-a/SREBP1c signaling pathway
W Zhu, M Chen, Y Wang, Y Chen, Y Zhang… - Chemico-Biological …, 2023 - Elsevier
Morroniside (MOR), a cyclic enol ether terpene glycoside isolated from Cornus officinalis,
has been shown to inhibit lipid accumulation, although the mechanism of action is uncertain …
has been shown to inhibit lipid accumulation, although the mechanism of action is uncertain …
[HTML][HTML] Long-term LDR exposure may induce cognitive impairments: a possible association through targeting gut microbiota-gut-brain axis
P Guo, MJ Lei, S Hu, Z Xu, Y Zhou, P Zhou… - … and Environmental Safety, 2023 - Elsevier
Environmental and occupational low-dose radiation (LDR) exposure may be harmful for
health but the previous reports regarding effect of LDR on cognition are contradictory. Here …
health but the previous reports regarding effect of LDR on cognition are contradictory. Here …
[HTML][HTML] 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione isolated from Averrhoa carambola L. root inhibits high glucose-induced EMT in HK-2 cells through …
J Li, Q Pang, X Huang, H Jiang, G Tang, H Yan… - Biomedicine & …, 2024 - Elsevier
Abstract Objective 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione (DMDD) isolated
from Averrhoa carambola L. root, has been proven therapeutic effects on diabetic kidney …
from Averrhoa carambola L. root, has been proven therapeutic effects on diabetic kidney …
Effects of sodium-glucose cotransporter 2 inhibitors on renal risk factors in patients with abnormal glucose metabolism: a meta-analysis of randomized controlled trials
M Li, J Zhang, G Yang, J Zhang, M Han… - European Journal of …, 2023 - Springer
Aims Several trials have assessed the antihyperglycemic effects of sodium-glucose
cotransporter 2 inhibitors (SGLT2Is) in patients with type 2 diabetes mellitus (T2DM). We …
cotransporter 2 inhibitors (SGLT2Is) in patients with type 2 diabetes mellitus (T2DM). We …