[PDF][PDF] Serotonin reduction in post-acute sequelae of viral infection

AC Wong, AS Devason, IC Umana, TO Cox… - Cell, 2023 - cell.com
Post-acute sequelae of COVID-19 (PASC," Long COVID") pose a significant global health
challenge. The pathophysiology is unknown, and no effective treatments have been found to …

[HTML][HTML] The type I interferon antiviral response in the choroid plexus and the cognitive risk in COVID-19

S Suzzi, A Tsitsou-Kampeli, M Schwartz - Nature immunology, 2023 - nature.com
The type I interferon (IFN) response is the body's typical immune defense against viruses.
Previous studies linked high expression of genes encoding type I IFNs in the brain's choroid …

Autoimmunity and SARS‐CoV‐2 infection: Unraveling the link in neurological disorders

D Latorre - European Journal of Immunology, 2022 - Wiley Online Library
Abstract According to the World Health Organization, severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) has already infected more than 400 million people and …

[PDF][PDF] Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients

M Khan, M Clijsters, S Choi, W Backaert, M Claerhout… - Neuron, 2022 - cell.com
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct and short route from
the nose into the brain? We reasoned that the neurotropic or neuroinvasive capacity of the …

[HTML][HTML] COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy

PP Zhang, ZC He, XH Yao, R Tang, J Ma… - … and Targeted Therapy, 2023 - nature.com
Severe neurological symptoms are associated with Coronavirus disease 2019 (COVID-19).
However, the morphologic features, pathological nature and their potential mechanisms in …

[HTML][HTML] Multifactorial white matter damage in the acute phase and pre-existing conditions may drive cognitive dysfunction after SARS-CoV-2 infection: neuropathology …

E Gelpi, S Klotz, M Beyerle, S Wischnewski, V Harter… - Viruses, 2023 - mdpi.com
Background: There is an urgent need to better understand the mechanisms underlying acute
and long-term neurological symptoms after COVID-19. Neuropathological studies can …

[HTML][HTML] Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia

T Wallach, M Raden, L Hinkelmann, M Brehm… - Frontiers in …, 2023 - frontiersin.org
Introduction The pandemic coronavirus disease 19 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and is marked by thromboembolic …

[HTML][HTML] SARS-CoV-2 and the nervous system: current perspectives

A Pattanaik, S Bhandarkar B, L Lodha, S Marate - Archives of Virology, 2023 - Springer
SARS-CoV-2 infection frequently causes neurological impairment in both adults and
children. Recent publications have described significant aspects of the viral pathophysiology …

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19

J Radke, J Meinhardt, T Aschman, RL Chua… - Nature …, 2024 - nature.com
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …

[HTML][HTML] SARS-CoV-2 omicron BA. 5 and XBB variants have increased neurotropic potential over BA. 1 in K18-hACE2 mice and human brain organoids

R Stewart, K Yan, SA Ellis, CR Bishop… - Frontiers in …, 2023 - frontiersin.org
The reduced pathogenicity of the omicron BA. 1 sub-lineage compared to earlier variants is
well described, although whether such attenuation is retained for later variants like BA. 5 …