Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

Potential therapeutic options for COVID-19: an update on current evidence

Z Niknam, A Jafari, A Golchin, F Danesh Pouya… - European journal of …, 2022 - Springer
Abstract SARS-CoV-2, a novel coronavirus, is the agent responsible for the COVID-19
pandemic and is a major public health concern nowadays. The rapid and global spread of …

Umbilical cord mesenchymal stromal cells as critical COVID-19 adjuvant therapy: a randomized controlled trial

IH Dilogo, D Aditianingsih, A Sugiarto… - Stem cells …, 2021 - academic.oup.com
One of the main causes of acute respiratory distress syndrome in coronavirus disease 2019
(COVID-19) is cytokine storm, although the exact cause is still unknown. Umbilical cord …

Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications

Y Huang, Q Wu, PKH Tam - International Journal of Molecular Sciences, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal,
homing, and low immunogenicity. These distinct biological characteristics have already …

Safety and efficacy study of allogeneic human menstrual blood stromal cells secretome to treat severe COVID-19 patients: clinical trial phase I & II

M Fathi-Kazerooni, S Fattah-Ghazi, M Darzi… - Stem Cell Research & …, 2022 - Springer
Abstract Background Cell-free Mesenchymal stromal cells (MSCs) have been considered
due to their capacity to modulate the immune system and suppress cytokine storms caused …

Mesenchymal stem cells-derived exosomes ameliorate lupus by inducing M2 macrophage polarization and regulatory T cell expansion in MRL/lpr mice

W Sun, S Yan, C Yang, J Yang, H Wang… - Immunological …, 2022 - Taylor & Francis
Previous studies have implicated that the transplantation of human umbilical cord
mesenchymal stem cells (hUC-MSCs) effectively alleviates systemic lupus erythematosus …

Cell therapy in patients with COVID-19 using Wharton's jelly mesenchymal stem cells: a phase 1 clinical trial

M Saleh, AA Vaezi, R Aliannejad… - Stem cell research & …, 2021 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have received particular attention
because of their ability to modulate the immune system and inhibit inflammation caused by …

Stem cell therapy potency in personalizing severe COVID-19 treatment

A Basiri, F Mansouri, A Azari, P Ranjbarvan… - Stem Cell Reviews and …, 2021 - Springer
Currently, there are no specific and efficient vaccines or drugs for COVID-19, particularly in
severe cases. A wide range of variations in the clinical symptoms of different patients …

Cell therapy strategies for COVID-19: Current approaches and potential applications

MM Zaki, E Lesha, K Said, K Kiaee… - Science …, 2021 - science.org
Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most
patients having a mild course, severe presentations have limited treatment options. COVID …

Immunomodulation of mesenchymal stem cells in acute lung injury: from preclinical animal models to treatment of severe COVID-19

JP Li, KH Wu, WR Chao, YJ Lee, SF Yang… - International Journal of …, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has been a major public health challenge …