Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of developing mental disorders in later life. However, no review has …

Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

The brain-derived neurotrophic factor (BDNF) has received considerable attention as a
potential biomarker of major depressive disorder (MDD) and antidepressant response. We …

Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

Major depressive disorder (MDD) affects millions of people worldwide and is a leading
cause of disability. Several theories have been proposed to explain its pathological …

Serotonergic psychedelics are emerging as potential antidepressant therapeutic tools, as
suggested in a recent randomized controlled trial with ayahuasca for treatment-resistant …

Childhood environment can have a profound impact on brain structure and function.
Epigenetic mechanisms have been shown to play a critical role in adaptive and maladaptive …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in
the brain, and is one of the most widely investigated molecule in psychiatric disorders. The …