Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer

H Paganetti - Physics in Medicine & Biology, 2014 - iopscience.iop.org
Proton therapy treatments are based on a proton RBE (relative biological effectiveness)
relative to high-energy photons of 1.1. The use of this generic, spatially invariant RBE within …

Clustered DNA double-strand breaks: biological effects and relevance to cancer radiotherapy

JA Nickoloff, N Sharma, L Taylor - Genes, 2020 - mdpi.com
Cells manage to survive, thrive, and divide with high accuracy despite the constant threat of
DNA damage. Cells have evolved with several systems that efficiently repair spontaneous …

Radiation-induced clustered DNA lesions: Repair and mutagenesis

E Sage, N Shikazono - Free Radical Biology and Medicine, 2017 - Elsevier
Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

Proton radiobiology

F Tommasino, M Durante - Cancers, 2015 - mdpi.com
In addition to the physical advantages (Bragg peak), the use of charged particles in cancer
therapy can be associated with distinct biological effects compared to X-rays. While heavy …

Heavy ion carcinogenesis and human space exploration

M Durante, FA Cucinotta - Nature Reviews Cancer, 2008 - nature.com
Before the human exploration of Mars or long-duration missions on the Earth's moon, the
risk of cancer and other diseases from space radiation must be accurately estimated and …

Formation of clustered DNA damage after high-LET irradiation: a review

M Hada, AG Georgakilas - Journal of radiation research, 2008 - ieeexplore.ieee.org
Radiation can cause as well as cure cancer. The risk of developing radiation-induced
cancer has traditionally been estimated from cancer incidence among survivors of the …

Carbon ion radiotherapy: a review of clinical experiences and preclinical research, with an emphasis on DNA damage/repair

O Mohamad, BJ Sishc, J Saha, A Pompos, A Rahimi… - Cancers, 2017 - mdpi.com
Compared to conventional photon-based external beam radiation (PhXRT), carbon ion
radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and …

Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival

E Sage, L Harrison - … Research/Fundamental and Molecular Mechanisms of …, 2011 - Elsevier
A clustered DNA lesion, also known as a multiply damaged site, is defined as≥ 2 damages
in the DNA within 1–2 helical turns. Only ionizing radiation and certain chemicals introduce …

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

GAP Cirrone, L Manti, D Margarone, G Petringa… - Scientific Reports, 2018 - nature.com
Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against
cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour …

Stress management in plants: examining provisional and unique dose-dependent responses

M Georgieva, V Vassileva - International Journal of Molecular Sciences, 2023 - mdpi.com
The purpose of this review is to critically evaluate the effects of different stress factors on
higher plants, with particular attention given to the typical and unique dose-dependent …