Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …

EJ Cheon, CE Bearden, D Sun… - Psychiatry and …, 2022 - Wiley Online Library
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …

[HTML][HTML] Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives

D van der Meer, T Kaufmann - Translational Psychiatry, 2022 - nature.com
Cortical morphology is a key determinant of cognitive ability and mental health. Its
development is a highly intricate process spanning decades, involving the coordinated …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

The genetic architecture of human cortical folding

D Van Der Meer, T Kaufmann, AA Shadrin… - Science …, 2021 - science.org
The folding of the human cerebral cortex is a highly genetically regulated process that
allows for a much larger surface area to fit into the cranial vault and optimizes functional …

Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in …

W Cheng, D van der Meer, N Parker, G Hindley… - Molecular …, 2022 - nature.com
Patients with schizophrenia have consistently shown brain volumetric abnormalities,
implicating both etiological and pathological processes. However, the genetic relationship …

The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study

W Cheng, N Parker, N Karadag, E Koch… - The Lancet …, 2023 - thelancet.com
Background The relationship between psychotic disorders and cannabis use is heavily
debated. Shared underlying genetic risk is one potential explanation. We investigated the …

Characterizing the shared genetic underpinnings of schizophrenia and cardiovascular disease risk factors

L Rødevand, Z Rahman, GFL Hindley… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Schizophrenia is associated with increased risk of cardiovascular disease (CVD),
although there is variation in risk among individuals. There are indications of shared genetic …

Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders

N Karadag, AA Shadrin, KS O'Connell, GFL Hindley… - Brain, 2023 - academic.oup.com
Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity
and overlapping symptoms. However, the causative mechanisms underlying this …

[HTML][HTML] Boosting schizophrenia genetics by utilizing genetic overlap with brain morphology

D Van der Meer, AA Shadrin, K O'Connell, F Bettella… - Biological …, 2022 - Elsevier
Background Schizophrenia is a complex polygenic disorder with subtle, distributed
abnormalities in brain morphology. There are indications of shared genetic architecture …

[HTML][HTML] Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia

LB Cui, XY Wang, YF Fu, XF Liu, Y Wei, SW Zhao… - BMC medicine, 2023 - Springer
Background Inflammation has been implicated in the pathology of schizophrenia and may
cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted …