Improvements in healthcare and nutrition have generated remarkable increases in life
expectancy worldwide. This is one of the greatest achievements of the modern world yet it …

Summary The National Institute on Aging Interventions Testing Program (ITP) evaluates
agents hypothesized to increase healthy lifespan in genetically heterogeneous mice. Each …

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

Here we review the environmental and genetic manipulations that link cellular and
organismal metabolism to aging. In particular, we explore how nutrients are sensed and how …

Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …

During aging, body adiposity increases with changes in the metabolism of lipids and their
metabolite levels. Considering lipid metabolism, excess adiposity with increased lipotoxicity …

Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …

Common chronic diseases represent the greatest driver of rising healthcare costs, as well as
declining function, independence, and quality of life. Geroscience‐guided approaches seek …

Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral
insulin resistance, ectopic lipid deposition, and inflammation. Fundamental aging …

Drosophila melanogaster has been a key model in developing our current understanding of
the molecular mechanisms of ageing. Of particular note is its role in establishing the …