Dengue virus is a mosquito-borne pathogen that causes up to about 100 million cases of
disease each year, placing a major public health, social, and economic burden on …

Dengue is a major public health issue in tropical and subtropical regions worldwide. The
four serotypes of dengue virus (DENV1–DENV4) are spread primarily by Aedes aegypti and …

For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to
enhance viral replication in vitro and severe disease in animal models. Although suspected …

Improved diagnostics for acute infections could decrease morbidity and mortality by
increasing early antibiotics for patients with bacterial infections and reducing unnecessary …

Dengue virus (DENV) infection induces the expansion of plasmablasts, which produce
antibodies that can neutralize DENV but also enhance disease upon secondary infection …

The dogma is that the human immune system protects us against pathogens. Yet, several
viruses, like dengue virus, antagonize the hosts' antibodies to enhance their viral load and …

The immune system plays a key role in health maintenance and pathogenesis of a wide
range of diseases. Leukocytes that are present in the blood convey valuable information …

Dendritic cells (DCs) are sentinels of the immune system and detect pathogens at sites of
entry, such as the skin. In addition to the ability of DCs to control infections directly via their …

Highlights•Biomarkers of severe dengue can potentially improve clinical dengue outcomes
and alleviate the healthcare burden in dengue-endemic settings.•Risk factors for severe …

There is a need to identify biomarkers predictive of severe dengue. Single-cohort
transcriptomics has not yielded generalizable results or parsimonious, predictive gene sets …