Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes,
and elevated GFR is a risk factor for the development of diabetic kidney disease …

Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Diabetic kidney disease (DKD) is one of the most serious complications of both type 1
(T1DM) and type 2 diabetes mellitus (T2DM). Current guidelines recommend a personalized …

Aims/hypothesis Type 2 diabetes is highly polygenic and influenced by multiple biological
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …

Associations between human genetic variation and clinical phenotypes have become a
foundation of biomedical research. Most repositories of these data seek to be disease …

Metabolic memory, the persistent benefits of early glycaemic control on preventing and/or
delaying the development of diabetic complications, has been observed in the Diabetes …