Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

In concert with neuropeptides and transmitters, the end products of the hypothalamus-
pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone …

Major depression is often a relapsing disorder. It is therefore important to start its treatment
with therapies that maximize the chance of not only getting the patients well but also keeping …

Introduction: Ketamine has emerged as a rapid-acting antidepressant. While ongoing
treatment can prevent relapse, concerns exist regarding long-term exposure. Objective: We …

Firmly grounded in contemporary clinical practice and research, this pragmatic guide for
professionals and students is now in a revised and expanded second edition. The book …

Introduction: Appraisal of prodromal symptoms of unipolar depression may complement the
traditional cross-sectional approach and provide a longitudinal perspective, according to a …

Euthymia is a trans-diagnostic construct characterized by lack of mood disturbances;
presence of positive affect; balance of psychological well-being dimensions, flexibility …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Importance Depression frequently recurs. To prevent relapse, antidepressant medication is
often taken in the long term. Sequentially delivering a psychological intervention while …

Objective: Previous work has demonstrated significant declines in the provision of outpatient
psychotherapy by US psychiatrists. The objective of this study was to characterize patterns …